Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.
Neural Netw. 2013 Nov;47:11-7. doi: 10.1016/j.neunet.2012.08.001. Epub 2012 Sep 5.
The Purkinje cells in the cerebellum are unique neurons that generate local and global Ca(2+) signals in response to two types of excitatory inputs, parallel fiber and climbing fiber, respectively. The spatiotemporal distribution and interaction of these synaptic inputs produce complex patterns of Ca(2+) dynamics in the Purkinje cell dendrites. The Ca(2+) signals originate from Ca(2+) influx through voltage-gated Ca(2+) channels and Ca(2+) release from intracellular stores that are mediated by the metabotropic glutamate receptor signaling pathway. These Ca(2+) signals are essential for the induction of various forms of synaptic plasticity and for controlling the input-output relationship of Purkinje cells. In this article we review Ca(2+) signaling in Purkinje cell dendrites.
小脑浦肯野细胞是独特的神经元，它们分别对两种兴奋性输入（平行纤维和 climbing 纤维）产生局部和全局 Ca(2+)信号。这些突触输入的时空分布和相互作用在浦肯野细胞树突中产生了复杂的 Ca(2+)动力学模式。Ca(2+)信号源于电压门控 Ca(2+)通道的 Ca(2+)内流和代谢型谷氨酸受体信号通路介导的细胞内储存的 Ca(2+)释放。这些 Ca(2+)信号对于诱导各种形式的突触可塑性以及控制浦肯野细胞的输入-输出关系至关重要。本文综述了浦肯野细胞树突中的 Ca(2+)信号。
