Helen Wills Neuroscience Institute, University of California, Berkeley, USA.
Neuroimage. 2013 Jan 1;64:416-24. doi: 10.1016/j.neuroimage.2012.09.023. Epub 2012 Sep 14.
Phase/amplitude coupling (PAC) is emerging as an important electrophysiological measure of local and long-distance neuronal communication. Current techniques for calculating PAC provide a numerical index that represents an average value across an arbitrarily long time period. This requires researchers to rely on block design experiments and temporal concatenation at the cost of the sub-second temporal resolution afforded by electrophysiological recordings. Here we present a method for calculating event-related phase/amplitude coupling (ERPAC) designed to capture the temporal evolution of task-related changes in PAC across events or between distant brain regions that is applicable to human or animal electromagnetic recording.
相位/振幅耦合（PAC）正在成为局部和远距离神经元通信的一种重要电生理测量方法。目前计算 PAC 的技术提供了一个数值指标，代表了任意长时间段的平均值。这要求研究人员依赖于块设计实验和时间串联，以牺牲电生理记录提供的亚秒级时间分辨率为代价。在这里，我们提出了一种计算事件相关相位/振幅耦合（ER-PAC）的方法，旨在捕获跨事件或在遥远脑区之间与任务相关的 PAC 变化的时间演变，适用于人类或动物的电磁记录。
