Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Atherosclerosis. 2012 Apr;221(2):587-95. doi: 10.1016/j.atherosclerosis.2012.01.034. Epub 2012 Jan 28.
The authors sought to investigate the relationship between dietary magnesium intake and mortality from cardiovascular disease in a population-based sample of Asian adults. Reported findings are based on dietary magnesium intake in 58,615 healthy Japanese aged 40-79 years, in the Japan Collaborative Cohort (JACC) Study. Dietary magnesium intake was assessed by a validated food frequency questionnaire administered between 1988 and 1990. During the median 14.7-year follow-up, we documented 2690 deaths from cardiovascular disease, comprising 1227 deaths from strokes and 557 deaths from coronary heart disease. Dietary magnesium intake was inversely associated with mortality from hemorrhagic stroke in men and with mortality from total and ischemic strokes, coronary heart disease, heart failure and total cardiovascular disease in women. The multivariable hazard ratio (95% CI) for the highest vs. the lowest quintiles of magnesium intake after adjustment for cardiovascular risk factor and sodium intake was 0.49 (0.26-0.95), P for trend = 0.074 for hemorrhagic stroke in men, 0.68 (0.48-0.96), P for trend = 0.010 for total stroke, 0.47 (0.29-0.77), P for trend < 0.001 for ischemic stroke, 0.50 (0.30-0.84), P for trend = 0.005 for coronary heart disease, 0.50 (0.28-0.87), P for trend = 0.002 for heart failure and 0.64 (0.51-0.80), P for trend < 0.001 for total cardiovascular disease in women. The adjustment for calcium and potassium intakes attenuated these associations. In conclusion, dietary magnesium intake was associated with reduced mortality from cardiovascular disease in Japanese, especially for women.
作者旨在探讨亚洲成年人中饮食镁摄入量与心血管疾病死亡率之间的关系。报告的研究结果基于日本协同队列研究（JACC）中 58615 名健康日本 40-79 岁成年人的饮食镁摄入量。饮食镁摄入量通过 1988 年至 1990 年之间进行的验证食物频率问卷进行评估。在中位 14.7 年的随访期间，我们记录了 2690 例心血管疾病死亡，其中 1227 例死于中风，557 例死于冠心病。饮食镁摄入量与男性出血性中风死亡率以及女性总中风、冠心病、心力衰竭和总心血管疾病死亡率呈负相关。在调整心血管危险因素和钠摄入量后，最高与最低五分位数镁摄入量的多变量风险比（95%CI）分别为：男性出血性中风 0.49（0.26-0.95），趋势 P 值=0.074；总中风 0.68（0.48-0.96），趋势 P 值=0.010；缺血性中风 0.47（0.29-0.77），趋势 P 值<0.001；冠心病 0.50（0.30-0.84），趋势 P 值=0.005；心力衰竭 0.50（0.28-0.87），趋势 P 值=0.002；总心血管疾病 0.64（0.51-0.80），趋势 P 值<0.001。钙和钾摄入量的调整削弱了这些关联。总之，饮食镁摄入量与日本人心血管疾病死亡率降低相关，尤其是女性。
