Feng Wei, Fu Li, Liu Jianguo, Li Dongsong, Qi Xin
Department of Orthopaedics, The First Hospital of Jilin University, Changchun, 130021, China.
Cell Tissue Bank. 2013 Sep;14(3):375-80. doi: 10.1007/s10561-012-9342-0. Epub 2012 Sep 18.
To investigate the clinical behavior of deep frozen and irradiated bone allografts in the treatment of depressed tibial plateau fractures. Twenty-two patients with a tibial plateau fracture were treated with cancellous bone allografts. The bone allograft preparation process included fresh-freezing at -70 °C for 4 weeks and gamma-irradiation at 25 kGy. All of the patients were followed for 1-2 years. The clinical effects were assessed using the Rasmussen score for tibial head fractures and X-rays. Postoperatively, the average excellent and fair Rasmussen scores were 88.9%. Only one patient developed an infection, with no integration between allograft and recipient bone observed. All of the other bone allografts were incorporated successfully, and no osteoporosis or sclerosis was observed. The frozen and gamma-irradiated bone allograft is a good alternative in the treatment of tibial plateau fractures, which we have shown can integrate with the surrounding host bone.
探讨深冻及辐照骨同种异体移植治疗胫骨平台凹陷骨折的临床疗效。22例胫骨平台骨折患者接受了松质骨同种异体移植治疗。骨同种异体移植的制备过程包括在-70℃新鲜冷冻4周和25 kGy的γ射线辐照。所有患者均随访1-2年。采用Rasmussen胫骨髁骨折评分和X线评估临床疗效。术后，Rasmussen评分优良率平均为88.9%。仅1例患者发生感染，未观察到同种异体骨与受体骨融合。其他所有同种异体骨均成功融合，未观察到骨质疏松或骨质硬化。冷冻及γ射线辐照的骨同种异体移植是治疗胫骨平台骨折的一种良好选择，我们已证明其可与周围宿主骨融合。
