Texas A&M Health Science Center, Cardiovascular Research Institute, 1901 South First St., Bldg 205, Temple, TX 76504, USA.
J Cardiovasc Transl Res. 2012 Dec;5(6):783-93. doi: 10.1007/s12265-012-9407-2. Epub 2012 Sep 18.
Treatment of cardiovascular diseases relies on the ability not only to abrogate and compensate for congenital deformities but also to repair cardiac pathologies in the adult. Determining how cells communicate within the myocardium and how to use this communication to repair and treat pathological conditions have been necessary steps in the successful intervention of cardiac diseases. In this regard, research has mostly focused on relationships between the main cellular constituents of the heart, myocytes, and fibroblasts. However, the coronary vasculature is also critical to myocardial organization and integrity, and how the vasculature influences and responds to cues from cardiac myocytes and fibroblasts is largely underappreciated. This review discusses how factors that affect myocyte and fibroblast physiology and communication may also interact with the coronary vasculature. Defining the mechanisms of these cellular relationships will help identify ways to control angiogenesis during cardiac remodeling and the development of tissue-engineered therapies.
心血管疾病的治疗不仅依赖于消除和补偿先天畸形的能力，还依赖于修复成人心血管疾病的能力。确定细胞在心肌内如何进行通信，以及如何利用这种通信来修复和治疗病理状况，是心脏疾病成功干预的必要步骤。在这方面，研究主要集中在心脏的主要细胞成分心肌细胞和成纤维细胞之间的关系上。然而，冠状动脉血管系统对于心肌组织和完整性也至关重要，血管系统如何影响和响应心肌细胞和成纤维细胞的信号在很大程度上还未被充分认识。这篇综述讨论了影响心肌细胞和成纤维细胞生理学和通信的因素如何与冠状动脉血管系统相互作用。确定这些细胞关系的机制将有助于确定在心脏重构和组织工程治疗发展过程中控制血管生成的方法。
