MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
IEEE Trans Neural Syst Rehabil Eng. 2013 Jan;21(1):32-6. doi: 10.1109/TNSRE.2012.2214058. Epub 2012 Sep 11.
The cardiovascular system can be influenced by electrically stimulating the vagal nerve. Selectivity for specific cardiac fibers may be limited when stimulating at the cervical level. Our objective was to increase effectiveness and selectivity for cardiovascular effects of vagal nerve stimulation by using local bipolar stimulation in one nerve cross section using a multi-contact cuff instead of less localized stimulation using a tripolar ring electrode. Both types of cuff electrodes were compared with respect to their relative effects on R-R interval (RRI), P-Q interval (PQI), left ventricular contractility (LVC), and left ventricular pressure (P(LV)) in seven pigs. Stimulation using the optimal bipolar configuration on the multi-contact cuff significantly affected RRI, PQI, LVC, and P(LV), whereas stimulation with the ring electrode only significantly affected RRI and PQI. The cardiovascular parameters that could be significantly influenced varied between the bipolar configurations. These novel findings may be relevant for optimizing electrode configurations for clinical cardiac applications of vagal nerve stimulation.
心血管系统可以通过电刺激迷走神经来影响。在颈部刺激时，对特定心脏纤维的选择性可能有限。我们的目的是通过使用多触点袖带在一个神经横截面上进行局部双极刺激，而不是使用三极环电极进行不太局部的刺激，来提高迷走神经刺激对心血管效应的有效性和选择性。将这两种袖带电极与它们在 7 头猪中的相对 RR 间期 (RRI)、PQ 间期 (PQI)、左心室收缩性 (LVC) 和左心室压力 (P(LV)) 影响进行了比较。使用多触点袖带上的最佳双极配置进行刺激显著影响了 RRI、PQI、LVC 和 P(LV)，而环电极刺激仅显著影响了 RRI 和 PQI。可以显著影响的心血管参数在双极配置之间有所不同。这些新发现可能与优化用于临床心脏迷走神经刺激的电极配置有关。
