The Mind Research Network, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
PLoS One. 2011;6(11):e26758. doi: 10.1371/journal.pone.0026758. Epub 2011 Nov 3.
To investigate the biochemical correlates of normal personality we utilized proton magnetic resonance spectroscopy ((1)H-MRS). Our sample consisted of 60 subjects ranging in age from 18 to 32 (27 females). Personality was assessed with the NEO Five-Factor Inventory (NEO-FFI). We measured brain biochemistry within the precuneus, the cingulate cortex, and underlying white matter. We hypothesized that brain biochemistry within these regions would predict individual differences across major domains of personality functioning. Biochemical models were fit for all personality domains including Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness. Our findings involved differing concentrations of Choline (Cho), Creatine (Cre), and N-acetylaspartate (NAA) in regions both within (i.e., posterior cingulate cortex) and white matter underlying (i.e., precuneus) the Default Mode Network (DMN). These results add to an emerging literature regarding personality neuroscience, and implicate biochemical integrity within the default mode network as constraining major personality domains within normal human subjects.
为了研究正常人格的生化相关性，我们利用了质子磁共振波谱（1H-MRS）。我们的样本包括 60 名年龄在 18 至 32 岁之间的受试者（27 名女性）。人格评估采用 NEO 五因素量表（NEO-FFI）。我们在楔前叶、扣带回皮层和下白质内测量了脑生物化学物质。我们假设这些区域的脑生物化学物质可以预测人格功能主要领域的个体差异。生物化学模型适用于包括神经质、外向性、开放性、宜人性和尽责性在内的所有人格领域。我们的研究结果涉及到默认模式网络（DMN）内的后扣带皮层和下白质内的不同脑区（即楔前叶）中胆碱（Cho）、肌酸（Cre）和 N-乙酰天冬氨酸（NAA）的浓度差异。这些结果增加了关于人格神经科学的新兴文献，并暗示了默认模式网络内的生化完整性作为限制正常人类受试者主要人格领域的因素。
