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聚合物纳米颗粒作为抗癌药物靶向和控释的载体。

Polymeric nanoparticles as carrier for targeted and controlled delivery of anticancer agents.

作者信息

Taghipour-Sabzevar Vahid, Sharifi Tahere, Moghaddam Mehrdad Moosazadeh

机构信息

Biomedical Engineering Division, Chemical Engineering Faculty, Tarbiat Modares University, Tehran, Iran.

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

出版信息

Ther Deliv. 2019 Aug;10(8):527-550. doi: 10.4155/tde-2019-0044. Epub 2019 Sep 9.

Abstract

In recent decades, many novel methods by using nanoparticles (NPs) have been investigated for diagnosis, drug delivery and treatment of cancer. Accordingly, the potential of NPs as carriers is very significant for the delivery of anticancer drugs, because cancer treatment with NPs has led to the improvement of some of the drug delivery limitations such as low blood circulation time and bioavailability, lack of water solubility, drug adverse effect. In addition, the NPs protect drugs against enzymatic degradation and can lead to the targeted and/or controlled release of the drug. The present review focuses on the potential of NPs that can help the targeted and/or controlled delivery of anticancer agents for cancer therapy.

摘要

近几十年来,人们研究了许多使用纳米颗粒(NPs)的新方法用于癌症的诊断、药物递送和治疗。因此,纳米颗粒作为载体在抗癌药物递送方面的潜力非常巨大,因为使用纳米颗粒进行癌症治疗已经改善了一些药物递送方面的局限性,如血液循环时间短、生物利用度低、缺乏水溶性、药物不良反应等。此外,纳米颗粒可保护药物不被酶降解,并可导致药物的靶向和/或控释。本综述重点关注纳米颗粒在帮助抗癌药物实现靶向和/或控释以用于癌症治疗方面的潜力。

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