专家观点：用于癌症治疗的响应性聚合物纳米粒子。
Expert opinion: Responsive polymer nanoparticles in cancer therapy.
机构信息
Department of Chemical Engineering, The University of Texas at Austin, TX 78731, USA.
出版信息
Eur J Pharm Biopharm. 2012 Feb;80(2):241-6. doi: 10.1016/j.ejpb.2011.08.004. Epub 2011 Aug 25.
Abstract
Polymeric nanoparticles are emerging as an attractive treatment options for cancer due to their favorable size distribution, drug carrying capacity, and tunable properties. In particular, intelligent nanoparticles that respond to biological cues are of interest because of their ability to provide controlled release at a specific site. Tumor sites display abnormal pH profiles and pathophysiology that can be exploited to provide localized release. In this expert opinion, we discuss passive and active targeting of nanoparticles and several classes of pH-responsive nanoparticles.
摘要
高分子纳米粒作为一种有吸引力的癌症治疗选择正在出现，这是由于它们具有良好的粒径分布、载药能力和可调性质。特别是，能够响应生物信号的智能纳米粒因其能够在特定部位提供控制释放而受到关注。肿瘤部位显示出异常的 pH 谱和病理生理学，可用于提供局部释放。在本专家意见中，我们讨论了纳米粒的被动和主动靶向以及几类 pH 响应纳米粒。
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