Department of Food Science and Nutrition, Faculty of Health Sciences, The Public Authority for Applied Education and Training, Al Faiha 72853, Kuwait.
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Harry Nursten Building, Pepper Lane, Reading RG6 6DZ, UK.
Nutrients. 2021 Jan 23;13(2):326. doi: 10.3390/nu13020326.
Metabolic diseases have been shown to be associated with low vitamin D status; however, the findings have been inconsistent. Hence, the objective of our study was to investigate the relationship between vitamin D status and metabolic disease-related traits in healthy Southeast Asian women and examine whether this relationship was modified by dietary factors using a nutrigenetic study. The study included 110 Minangkabau women (age: 25-60 years) from Padang, Indonesia. Genetic risk scores (GRS) were constructed based on five vitamin D-related single nucleotide polymorphisms (SNPs) (vitamin D-GRS) and ten metabolic disease-associated SNPs (metabolic-GRS). The metabolic-GRS was significantly associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations ( = 0.009) and higher body mass index (BMI) ( = 0.016). Even though the vitamin D-GRS had no effect on metabolic traits ( > 0.12), an interaction was observed between the vitamin D-GRS and carbohydrate intake (g) on body fat percentage (BFP) ( = 0.049), where those individuals who consumed a high carbohydrate diet (mean ± SD: 319 g/d ± 46) and carried >2 vitamin D-lowering risk alleles had significantly higher BFP ( = 0.016). In summary, we have replicated the association of metabolic-GRS with higher BMI and lower 25(OH)D concentrations and identified a novel interaction between vitamin D-GRS and carbohydrate intake on body fat composition.
代谢疾病与维生素 D 状态较低有关；然而，研究结果并不一致。因此，我们的研究目的是调查维生素 D 状态与健康东南亚女性代谢疾病相关特征之间的关系，并使用营养遗传学研究来检验这种关系是否受饮食因素的影响。该研究纳入了来自印度尼西亚巴东的 110 名米南卡保女性（年龄：25-60 岁）。根据五个维生素 D 相关的单核苷酸多态性（SNP）（维生素 D-GRS）和十个代谢疾病相关的 SNP（代谢-GRS）构建了遗传风险评分（GRS）。代谢-GRS 与较低的 25-羟维生素 D（25(OH)D）浓度显著相关（=0.009）和较高的体重指数（BMI）显著相关（=0.016）。尽管维生素 D-GRS 对代谢特征没有影响（>0.12），但在维生素 D-GRS 和碳水化合物摄入量（g）与体脂肪百分比（BFP）之间观察到了相互作用（=0.049），即那些摄入高碳水化合物饮食（平均值±标准差：319 g/d ± 46）和携带>2 个降低维生素 D 风险等位基因的个体的 BFP 显著更高（=0.016）。综上所述，我们复制了代谢-GRS 与较高的 BMI 和较低的 25(OH)D 浓度之间的关联，并确定了维生素 D-GRS 和碳水化合物摄入之间对体脂肪成分的新的相互作用。
