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Appl Environ Microbiol. 2011 Oct;77(20):7134-41. doi: 10.1128/AEM.05087-11. Epub 2011 Aug 5.
3
Genetic diversity and antibiotic resistance in Shigella dysenteriae and Shigella boydii strains isolated from children aged <5 years in Egypt.从埃及 <5 岁儿童中分离的志贺氏痢疾杆菌和鲍氏志贺氏菌菌株的遗传多样性和抗生素耐药性。
Epidemiol Infect. 2012 Feb;140(2):299-310. doi: 10.1017/S0950268811000525. Epub 2011 Apr 7.
4
Multi-drug resistance and characteristic of integrons in Shigella spp. isolated from China.中国志贺菌属中分离的多重耐药性及其整合子特征。
Biomed Environ Sci. 2011 Feb;24(1):56-61. doi: 10.3967/0895-3988.2011.01.007.
5
Antimicrobial resistance patterns and prevalence of class 1 and 2 integrons in Shigella flexneri and Shigella sonnei isolated in Uzbekistan.在乌兹别克斯坦分离的福氏志贺菌和宋内志贺菌的抗菌药物耐药模式和 1 类及 2 类整合子的流行情况。
Gut Pathog. 2010 Dec 9;2(1):18. doi: 10.1186/1757-4749-2-18.
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J Infect Dev Ctries. 2010 May 1;4(4):207-12. doi: 10.3855/jidc.583.
7
Antimicrobial resistance patterns and characterization of integrons of Shigella sonnei isolates in Seoul, 1999-2008.1999-2008 年首尔宋内志贺菌分离株的抗生素耐药模式和整合子特征。
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8
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Utility of multilocus variable-number tandem-repeat analysis as a molecular tool for phylogenetic analysis of Shigella sonnei.多位点可变数目串联重复序列分析作为宋内志贺氏菌系统发育分析分子工具的效用
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1999-2005 年埃及儿童分离的宋内志贺菌生物型 g 的比较分析。

Comparative analysis of Shigella sonnei biotype g isolated from paediatric populations in Egypt, 1999-2005.

机构信息

Clinical Trials and Military Studies Program, U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.

出版信息

Epidemiol Infect. 2013 Aug;141(8):1614-24. doi: 10.1017/S0950268812002002. Epub 2012 Sep 19.

DOI:10.1017/S0950268812002002
PMID:22989417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9151601/
Abstract

Strain characteristics of 51 Shigella sonnei isolates obtained from children seeking medical care (MC) and 48 isolates recovered during a prospective diarrhoea birth cohort (BC) study were compared. Biochemical characterization and antibiotic susceptibility testing determined that all S. sonnei isolates were biotype g and multidrug-resistant. Plasmid profiling identified 15 closely related patterns and XbaI pulsed-field gel electrophoresis confirmed the high degree of genetic similarity between isolates. All S. sonnei isolates harboured ipaH and class II integrase genes and 84∙3 and 80% of the MC and BC isolates, respectively carried the sen gene. Neither the class I integrase nor the set gene was detected. Our results indicate that S. sonnei isolates associated with severe diarrhoea were indistinguishable from those associated with mild diarrhoea. Additional genetic tests with greater discrimination might offer an opportunity to determine genetic differences within the globally disseminating biotype g clone.

摘要

比较了从寻求医疗（MC）的儿童中获得的 51 株宋内志贺菌分离株和前瞻性腹泻出生队列（BC）研究中回收的 48 株分离株的菌株特征。生化特征和抗生素药敏试验确定所有宋内志贺菌分离株均为生物型 g 和多药耐药。质粒图谱分析确定了 15 种密切相关的模式，XbaI 脉冲场凝胶电泳证实了分离株之间的高度遗传相似性。所有宋内志贺菌分离株均携带 ipaH 和类 II 整合酶基因，MC 和 BC 分离株中分别有 84.3%和 80%携带 sen 基因。未检测到类 I 整合酶或 set 基因。我们的结果表明，与严重腹泻相关的宋内志贺菌分离株与与轻度腹泻相关的分离株无法区分。具有更高鉴别力的其他遗传测试可能有机会确定在全球传播的生物型 g 克隆内的遗传差异。