Department of Pharmacology, School of Medicine, Catholic University of Daegu, Daegu, South Korea.
Chemosphere. 2013 Feb;90(5):1603-9. doi: 10.1016/j.chemosphere.2012.08.035. Epub 2012 Sep 16.
This study analyzed the concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexane sulfonate (PFHxS) in maternal and umbilical cord sera at delivery from the general population in Korea. Seventy samples were analyzed with ion-pairing and LC/MS/MS. PFOS, PFOA and PFHxS were detected in both maternal and umbilical cord sera. There was a high correlation of PFC concentrations between maternal and cord serum samples, implying transplacental transport. Ranking of transplacental transfer efficiency was PFOA>PFHxS>PFOS. Student's t-tests revealed that concentrations of maternal PFOA were related with decreases in birth weight, birth length and ponderal index, suggesting a possible impact on fetal growth. With multiple logistic regression models, maternal PFOS concentration showed a significant inverse association with ponderal index (OR=0.22; 95% CI, 0.05-0.90). Umbilical cord PFHxS concentration showed a significant inverse association with birth weight (OR=0.26; 95% CI, 0.08-0.85) or a marginally significant inverse association with birth length (OR=0.33; 95% CI, 0.09-1.17). This is the first report demonstrating an inverse association of birth outcomes with PFHxS exposure. Concentrations of maternal PFOA were decreased with parity, implying that delivery is one of the major routes for PFOA elimination in women. This study demonstrated prenatal exposure of PFCs through placental transfer which could result in possible developmental effects in the population sampled. Our results may provide data basis to conduct a larger scale investigation into developmental effects of PFCs in the future and contribute to understanding levels of PFC contaminations from a variety of populations in the globe.
本研究分析了来自韩国普通人群的产妇和脐带血清中全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和全氟己烷磺酸（PFHxS）的浓度。用离子对和 LC/MS/MS 分析了 70 个样本。在产妇和脐带血清中均检测到 PFOS、PFOA 和 PFHxS。母体和脐带血清样本中 PFC 浓度相关性高，提示存在胎盘转运。胎盘转运效率的排序为 PFOA>PFHxS>PFOS。学生 t 检验显示，母体 PFOA 浓度与出生体重、出生体长和体重指数降低有关，表明可能对胎儿生长有影响。通过多元逻辑回归模型，母体 PFOS 浓度与体重指数呈显著负相关（OR=0.22；95%CI，0.05-0.90）。脐带 PFHxS 浓度与出生体重呈显著负相关（OR=0.26；95%CI，0.08-0.85）或与出生体长呈边缘显著负相关（OR=0.33；95%CI，0.09-1.17）。这是首次报告表明 PFHxS 暴露与出生结局呈负相关。母体 PFOA 浓度随产次减少，表明分娩是妇女体内 PFOA 消除的主要途径之一。本研究表明 PFC 通过胎盘转移进入胎儿体内，可能对所采样人群产生潜在的发育影响。我们的研究结果为未来开展更大规模的 PFC 发育影响研究提供了数据基础，并有助于了解全球不同人群中 PFC 污染的水平。
