Department of Neurology, Rabin Medical Center-Beilinson Campus, 49100 Petach Tikva, Israel.
Curr Neurol Neurosci Rep. 2012 Dec;12(6):680-6. doi: 10.1007/s11910-012-0313-4.
Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, opportunistic viral infection of the central nervous system that is mainly seen in the context of AIDS and certain monoclonal immune-suppressive therapies. The causative agent, a polyoma virus, named JC virus infects only humans and there is no animal model for PML. This update focuses on information gathered in recent years on the pathogenesis of the disorder, on several clinical aspects associated with diagnosis and therapy, and on the immune reconstitution inflammatory syndrome (IRIS), a complication associated with removal of immunosuppressive therapy in PML.
进行性多灶性白质脑病（PML）是一种严重的、常致命的中枢神经系统机会性病毒感染，主要发生在艾滋病和某些单克隆免疫抑制治疗的背景下。病原体为多瘤病毒，命名为 JC 病毒，仅感染人类，没有 PML 的动物模型。本更新重点介绍近年来在该疾病发病机制、与诊断和治疗相关的几个临床方面以及免疫重建炎症综合征（IRIS）方面收集的信息，IRIS 是 PML 中免疫抑制治疗去除相关的并发症。
