Rogers R L, Meyer J S, Mortel K F
Cerebral Blood Flow Laboratory, Veterans Administration Medical Center, Houston, TX 77211.
J Am Geriatr Soc. 1990 Feb;38(2):123-8. doi: 10.1111/j.1532-5415.1990.tb03472.x.
Among neurologically normal volunteers approaching age 65 with an option for retirement, a four-year prospective longitudinal study was designed to examine effects of different levels of physical activity on cerebral perfusion by between-group comparisons. After the fourth year, cognitive performance was also tested. Three groups were compared, each composed of 30 elderly volunteers, assigned as follows: Group 1, who continued to work; Group 2, who retired but participated in regular physical activities; and Group 3, who retired but did not participate in regular, planned physical activities. Retirees who elected to become physically inactive exhibited significant declines in cerebral blood flow (CBF) throughout four years of follow-up. Those who continued to work or retirees who elected to participate in regular activities sustained more constant CBF levels. Active retirees and those who continued to work also scored better on cognitive testing after the fourth year of follow-up compared to inactive retirees.
在接近65岁且有退休选择的神经功能正常的志愿者中，设计了一项为期四年的前瞻性纵向研究，通过组间比较来研究不同水平的体育活动对脑灌注的影响。在第四年之后，还测试了认知能力。比较了三组，每组由30名老年志愿者组成，分配如下：第一组，继续工作的人；第二组，退休但参加定期体育活动的人；第三组，退休但不参加定期、有计划体育活动的人。选择不进行体育活动的退休人员在四年的随访中脑血流量（CBF）显著下降。继续工作的人和选择参加定期活动的退休人员的脑血流量水平更稳定。与不活动的退休人员相比，积极的退休人员和继续工作的人在随访第四年后的认知测试中得分也更高。
