抗酿酒酵母抗体在格雷夫斯病中升高，但在桥本甲状腺炎中不升高。

Anti-Saccharomyces cerevisiae antibodies are elevated in Graves' disease but not in Hashimoto's thyroiditis.

机构信息

Research Unit (03UR/07-02), Faculty of Pharmacy, Monastir, Tunisia.

出版信息

Endocr Res. 2013;38(2):98-104. doi: 10.3109/07435800.2012.723293. Epub 2012 Sep 19.

DOI:10.3109/07435800.2012.723293

PMID:22992126

Abstract

BACKGROUND

Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease, but they had also been found in many other autoimmune diseases.

AIM

The aim of this study was to evaluate the prevalence of ASCA in patients with autoimmune thyroid disease (AITD).

PATIENTS AND METHODS

One hundred and ninety-seven patients with AITD and 160 healthy controls were included in the study. One hundred and nineteen patients had Graves' disease (GD) and 78 patients had Hashimoto's thyroiditis (HT). ASCA IgG and IgA were determined by ELISA.

RESULTS

ASCA IgG were significantly more frequent in patients with GD than in control group (11.8% vs. 3.1%, p = 0.002). In HT, the frequency of ASCA IgG was similar to that of the control group (3.8% and 3.1% respectively). The frequency of ASCA IgA was similar in GD (0.8%), HT (2.6%), and the control group (3.1%). In all GD patients, the frequency of ASCA IgG was significantly higher than that of ASCA IgA (11.8% vs. 0.8%, p = 0.001). These results were also true even in male and female groups (10.4% vs. 1.3%, p = 0.01 and 14.3% vs. 0%, p = 0.01, respectively). ASCA IgG levels were significantly higher in GD patients (6.7 ± 11.1 vs. 2.2 ± 2.8, p = 3 × 10(-6)) and in HT patients (4.2 ± 4.7 vs. 2.2 ± 2.8, p = 0.0002) than those in the control group. ASCA IgA levels were comparable among patients with GD, HT, and the control group. In GD patients, the mean titer of ASCA IgG was significantly higher than that of ASCA IgA (6.7 ± 11.1 vs. 3.6 ± 4.2, p = 0.005).

CONCLUSION

Patients with GD had a higher frequency of ASCA IgG than controls.

摘要

背景

抗酿酒酵母抗体（ASCA）以前被认为是克罗恩病的特异性抗体，但也在许多其他自身免疫性疾病中被发现。

目的

本研究旨在评估自身免疫性甲状腺疾病（AITD）患者中 ASCA 的患病率。

患者和方法

本研究纳入了 197 例 AITD 患者和 160 名健康对照者。119 例患者患有格雷夫斯病（GD），78 例患者患有桥本甲状腺炎（HT）。通过 ELISA 法测定 ASCA IgG 和 IgA。

结果

GD 患者的 ASCA IgG 频率明显高于对照组（11.8%比 3.1%，p=0.002）。在 HT 中，ASCA IgG 的频率与对照组相似（分别为 3.8%和 3.1%）。GD 患者的 ASCA IgA 频率（0.8%）、HT 患者（2.6%）和对照组（3.1%）相似。在所有 GD 患者中，ASCA IgG 的频率明显高于 ASCA IgA（11.8%比 0.8%，p=0.001）。即使在男性和女性组中，这些结果也是如此（10.4%比 1.3%，p=0.01 和 14.3%比 0%，p=0.01）。GD 患者的 ASCA IgG 水平明显高于对照组（6.7±11.1 比 2.2±2.8，p=3×10(-6)）和 HT 患者（4.2±4.7 比 2.2±2.8，p=0.0002）。GD 患者、HT 患者和对照组患者的 ASCA IgA 水平相当。在 GD 患者中，ASCA IgG 的平均滴度明显高于 ASCA IgA（6.7±11.1 比 3.6±4.2，p=0.005）。