University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford, UK.
Expert Rev Clin Immunol. 2012 Aug;8(6):547-55. doi: 10.1586/eci.12.45.
Dendritic cells (DCs) possess the specialized potential to present exogenously derived antigen to cytotoxic T lymphocytes to elicit an immune response. This process, termed cross presentation, is crucial in the generation of immune response to viruses, tumors and in autoimmune disease. The ability of DCs to cross-present exogenous antigen to cytotoxic T lymphocytes makes them an attractive target for exploitation in immunotherapy. In recent years, significant advances have been made in understanding the mechanism of cross-presentation and the DC subsets involved. The recent discovery of the human cross presenting DC has given this field a new lease of life. In this report, the authors provide an overview of cross-presentation of antigen by DCs, focusing on the current understanding of the molecular mechanisms of the process. The authors also discuss the DC subsets involved in cross presentation and its role in health and disease.
树突状细胞 (DCs) 具有将外源衍生抗原呈递给细胞毒性 T 淋巴细胞以引发免疫反应的特殊潜力。这种过程称为交叉呈递，对于产生针对病毒、肿瘤和自身免疫性疾病的免疫反应至关重要。DC 能够将外源抗原交叉呈递给细胞毒性 T 淋巴细胞，这使它们成为免疫疗法中极具吸引力的靶点。近年来，人们在理解交叉呈递机制和涉及的 DC 亚群方面取得了重大进展。人类交叉呈递 DC 的最近发现为该领域带来了新的活力。在本报告中，作者概述了 DC 对抗原的交叉呈递，重点介绍了该过程的分子机制的当前理解。作者还讨论了涉及交叉呈递的 DC 亚群及其在健康和疾病中的作用。
