Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Tumor Immunology Laboratory, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands.
Trends Immunol. 2013 Aug;34(8):361-70. doi: 10.1016/j.it.2013.02.007. Epub 2013 Mar 27.
Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each DC subset is tuned by and dependent on several factors, such as DC location and activation status, and the type of antigen and inflammatory signals. Thus, we argue that capacity of cross-presentation is not an exclusive trait of one or several distinct DC subtypes, but rather a common feature of the DC family in both mice and humans. Understanding DC subset activation and antigen-presentation pathways might yield improved tools and targets to exploit the unique cross-presenting capacity of DCs in immunotherapy.
抗原交叉呈递描述了树突状细胞 (DC) 获取外源抗原并在 MHC Ⅰ类分子上呈递的过程。交叉呈递的能力被认为是专门的 DC 亚群的特征。然而，新出现的数据表明，每个 DC 亚群的交叉呈递能力受到多种因素的调节和依赖，如 DC 的位置和激活状态，以及抗原和炎症信号的类型。因此，我们认为，交叉呈递的能力不是一个或几个独特的 DC 亚型所特有的，而是小鼠和人类 DC 家族的共同特征。了解 DC 亚群的激活和抗原呈递途径可能会产生更好的工具和靶点，以利用 DC 的独特交叉呈递能力进行免疫治疗。
