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Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck.头颈部鳞状细胞癌患者中磷酸化的腺苷酸活化蛋白激酶与乙酰辅酶A羧化酶表达及预后的关系
PLoS One. 2014 Apr 25;9(4):e96183. doi: 10.1371/journal.pone.0096183. eCollection 2014.

核蛋白激酶 CβII 高表达是口腔鳞状细胞癌疾病复发的一个标志物。

High nuclear protein kinase CβII expression is a marker of disease recurrence in oral squamous cell carcinoma.

机构信息

Department of Pathology, St Martin De Porres Hospital, Chiayi, Taiwan, ROC.

出版信息

Anticancer Res. 2012 Sep;32(9):3987-91.

PMID:22993348
Abstract

BACKGROUND

Protein kinase C beta II (PKCβII) is a member of the family of serine/threonine kinases which are involved in tumor formation and progression. This study investigated the significance of PKCβII in oral squamous cell carcinoma (OSCC).

PATIENTS AND METHODS

The expression of PKCβII was determined in tumors from 59 patients with OSCC using immunohistochemistry and was correlated with patients' clinical characteristics and outcomes.

RESULTS

Twenty-six cases (44%) exhibited nuclear PKCβII staining. High nuclear PKCβII expression was significantly associated with the consumption of betel quid (p=0.015) and alcohol (p=0.024) in OSCC. Kaplan-Meier analysis revealed a shorter time-to-recurrence in patients with high nuclear PKCβII expression (p=0.018). In multivariate analysis for recurrence, high nuclear staining of PKCβII remained an independent adverse prognostic factor (hazard ratio=2.3, p=0.016).

CONCLUSION

The present study provides evidence of the potential prognostic value of PKCβII analysis in OSCC.

摘要

背景

蛋白激酶 Cβ II（PKCβII）是丝氨酸/苏氨酸激酶家族的成员，该家族参与肿瘤的形成和进展。本研究调查了 PKCβII 在口腔鳞状细胞癌（OSCC）中的意义。

患者与方法

使用免疫组织化学法检测 59 例 OSCC 患者肿瘤中的 PKCβII 表达，并将其与患者的临床特征和结局相关联。

结果

26 例（44%）表现为核 PKCβII 染色。高核 PKCβII 表达与 OSCC 患者咀嚼槟榔（p=0.015）和饮酒（p=0.024）显著相关。Kaplan-Meier 分析显示，高核 PKCβII 表达的患者复发时间更短（p=0.018）。在复发的多变量分析中，高核 PKCβII 染色仍然是独立的不良预后因素（风险比=2.3，p=0.016）。

结论

本研究为 PKCβII 分析在 OSCC 中的潜在预后价值提供了证据。