Budin Siti Balkis, Kee Kwa Poi, Eng Monica Yau Swee, Osman Khairul, Bakar Mokhtar Abu, Mohamed Jamaludin
Biomedical Department, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Malays J Med Sci. 2007 Jul;14(2):47-53.
In the present study, the effects of alpha lipoic acid (ALA) supplementation on glycemic control and lipid profile in streptozotocin (STZ)-induced diabetic rats have been evaluated. Sprague Dawley rats were divided into nondiabetic (NDM), diabetic without supplementation (No Suppl) and diabetic with ALA groups. ALA was orally administered once a day for 8 weeks with a dose of 100 mg/kg BW. Supplementation of ALA to STZ-induced rats prevented the severe damage to the islet cells of the pancreas and lowered the plasma glucose and glycated hemoglobin (HbA1c) levels. Supplementation of ALA also suppressed the increased of total cholesterol (TC), triglycerides and low density lipoprotein-cholesterol (LDL-C) levels in the plasma of diabetic rats as well as increased high density lipoproteincholesterol (HDL-C) levels. In conclusion, this study suggest that ALA may be effective in controlling glycemic status and improving dyslipidemia in streptozotocin-induced diabetic rats and has the potential in reducing cardiovascular complications due to diabetes mellitus.
在本研究中，已评估了补充α硫辛酸（ALA）对链脲佐菌素（STZ）诱导的糖尿病大鼠血糖控制和血脂水平的影响。将Sprague Dawley大鼠分为非糖尿病组（NDM）、未补充组（未补充）和ALA糖尿病组。ALA以100 mg/kg体重的剂量每天口服一次，持续8周。给STZ诱导的大鼠补充ALA可防止胰腺胰岛细胞受到严重损伤，并降低血浆葡萄糖和糖化血红蛋白（HbA1c）水平。补充ALA还抑制了糖尿病大鼠血浆中总胆固醇（TC）、甘油三酯和低密度脂蛋白胆固醇（LDL-C）水平的升高，并提高了高密度脂蛋白胆固醇（HDL-C）水平。总之，本研究表明，ALA可能对控制链脲佐菌素诱导的糖尿病大鼠的血糖状态和改善血脂异常有效，并具有降低糖尿病心血管并发症的潜力。
