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局部使用“安卡福得止血剂”成功治疗婴儿血管瘤反复出血

Successful use of topical "Ankaferd Blood Stopper" for repetitive bleedings in an infant with infantile hemangioma.

作者信息

Annagür Ali, Altunhan Hüseyin, Konak Murat, Ors Rahmi

机构信息

Department of Pediatri, Selcuk University, Selçuklu Medical Faculty Konya, Turkey.

出版信息

Int J Clin Exp Med. 2012;5(4):342-5. Epub 2012 Aug 22.

PMID:22993655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3443886/
Abstract

Infantile hemangioma (IH) is the most common vascular tumor of childhood. A major feature of this tumor is rapid growth during a proliferation phase in the first year of life, followed by contraction through a slow involution phase. Several complications may emerge during this course. Bleeding at the site of the lesion and infection are the most common complications. 'Ankaferd Blood Stopper' (ABS) is a hemostatic agent produced as a mixture of five separate plant extracts. Provision of hemostasis by ABS is independent from coagulation factors and the standard coagulation cascade. Furthermore, ABS has an antimicrobial effect. In this article, we have presented a seven-year-old infant with IH on the lower lip who had been admitted with the symptoms of frequent bleedings and infection, and who was successfully treated with topical ABS in terms of control of bleeding and infection. To the best of our knowledge, this is the first reported case of IH that has been treated with ABS for bleeding.

摘要

婴儿血管瘤(IH)是儿童期最常见的血管肿瘤。这种肿瘤的一个主要特征是在生命的第一年增殖期快速生长,随后通过缓慢的消退期收缩。在此过程中可能会出现几种并发症。病变部位出血和感染是最常见的并发症。“安卡芬德止血剂”(ABS)是一种由五种不同植物提取物混合而成的止血剂。ABS止血独立于凝血因子和标准凝血级联反应。此外,ABS具有抗菌作用。在本文中,我们介绍了一名7岁下唇患有IH的婴儿,该婴儿因频繁出血和感染症状入院,通过局部应用ABS成功控制了出血和感染。据我们所知,这是首例报道用ABS治疗出血的IH病例。

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本文引用的文献

1
Propranolol for treatment of ulcerated infantile hemangiomas.普萘洛尔治疗溃疡性婴幼儿血管瘤。
J Am Acad Dermatol. 2011 May;64(5):827-32. doi: 10.1016/j.jaad.2010.12.040. Epub 2011 Feb 25.
2
Infantile hemangioma: an update.婴儿血管瘤:更新。
Indian J Dermatol Venereol Leprol. 2010 Sep-Oct;76(5):469-75. doi: 10.4103/0378-6323.69048.
3
Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper.安卡福凝止血胶成功治疗一名有止血功能缺陷的上消化道出血患者。
Phytother Res. 2011 Feb;25(2):312-3. doi: 10.1002/ptr.3252.
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Current management of infantile hemangiomas.婴儿血管瘤的当前管理
Semin Cutan Med Surg. 2010 Jun;29(2):106-14. doi: 10.1016/j.sder.2010.03.009.
5
Successful management of a difficult case of radiation proctopathy with Ankaferd BloodStopper: a novel indication (with video).用安卡福得止血剂成功治疗一例难治性放射性直肠炎:一种新的适应症(附视频)
Gastrointest Endosc. 2010 Sep;72(3):666-7. doi: 10.1016/j.gie.2009.12.018. Epub 2010 Apr 24.
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Prospective, randomized, controlled clinical trial of Ankaferd Blood Stopper in patients with acute anterior epistaxis.前瞻性、随机、对照临床试验评估 Ankaferd 血速停治疗急性前鼻出血的效果。
Eur Arch Otorhinolaryngol. 2010 Sep;267(9):1377-81. doi: 10.1007/s00405-010-1208-0. Epub 2010 Feb 13.
7
Oral systemic administration of Ankaferd blood stopper has no short-term toxicity in an in vivo rabbit experimental model.口服安可血塞停在兔体内实验模型中无短期毒性。
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