Parhar Kuljit S, Gibson Paul S, Coffin Carla S
Division of General Internal Medicine, University of Calgary, Calgary, Alberta.
Can J Gastroenterol. 2012 Sep;26(9):621-6. doi: 10.1155/2012/137129.
Liver transplantation is considered to be the treatment of choice for end-stage liver disease and its success has led to an increase in the number of female liver transplant recipients who are of childbearing age. Several key issues that are noted when counselling patients who are considering pregnancy following liver transplantation include the optimal timing of pregnancy, optimal contraception methods and the management of immunosuppression during pregnancy. The present review summarizes the most recent literature so that the clinician may address these issues with their patient and enable them to make informed decisions about pregnancy planning. The authors review recent studies examining maternal and fetal outcomes, and the rates of complications including risk of graft rejection. Subsequently, the authors provide recommendations for counselling prospective mothers and the management of the pregnant liver transplant recipient.
肝移植被认为是终末期肝病的首选治疗方法，其成功使得育龄期女性肝移植受者的数量有所增加。在为考虑肝移植后妊娠的患者提供咨询时，需要注意几个关键问题，包括最佳妊娠时机、最佳避孕方法以及孕期免疫抑制的管理。本综述总结了最新的文献，以便临床医生能够与患者讨论这些问题，并使他们能够就妊娠计划做出明智的决定。作者回顾了近期研究母婴结局以及并发症发生率（包括移植物排斥风险）的研究。随后，作者为咨询准母亲以及管理妊娠肝移植受者提供了建议。
