水朝阳旋覆花中的倍半萜内酯

Sesquiterpene lactones from Inula helianthus-aquatica.

作者信息

Hua Yaping, Qin Jiangjiang, Zhang Fei, Cheng Xiangrong, Jin Huizi, Zhang Weidong

机构信息

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1586-9.

PMID:22993986

Abstract

OBJECTIVE

To investigate the sesquiterpene lactones of the aerial parts of Inula helianthus-aquatica.

METHOD

Compounds were isolated and purified by silica gel, Sephadex LH-20 and preparative HPLC. On the basis of physicochemical properties and spectroscopic data, their structures were identified.

RESULT

Seven sesquiterpene lactones and four other compounds were obtained and identified as 2-desoxy-4-epi-pulchellin (1), 6-acetoxy-4-hydroxy-1, 10H-pseudoguaia-11 (13)-en-12,8-olide (2), 4-acetoxy-6-hydroxy-1, 10H-pseudoguaia-11(13)-en-12,8-olide (3), 8-epi-inuviscolide (4), 2,3,11,13-tetrahydroaromaticin (5), 11,13-dihydro-ergolide (6), 4-epipulchellin-2-O-acetate (7), 7-epiloliolide (8), loliolide (9), beta-sitosterol (10) and daucosterol (11).

CONCLUSION

All the compounds were isolated from this plant for the first time.

摘要

目的

研究水朝阳旋覆花地上部分的倍半萜内酯。

方法

采用硅胶柱色谱、葡聚糖凝胶LH-20柱色谱和制备型高效液相色谱法对化合物进行分离纯化。根据其理化性质和光谱数据鉴定其结构。

结果

得到7个倍半萜内酯和4个其他化合物，分别鉴定为2-脱氧-4-表普氏千里光碱（1）、6-乙酰氧基-4-羟基-1,10H-伪愈创木-11（13）-烯-12,8-内酯（2）、4-乙酰氧基-6-羟基-1,10H-伪愈创木-11（13）-烯-12,8-内酯（3）、8-表异土木香内酯（4）、2,3,11,13-四氢芳香苦内酯（5）、11,13-二氢麦角甾内酯（6）、4-表普氏千里光碱-2-O-乙酸酯（7）、7-表裂环马钱子苷（8）、裂环马钱子苷（9）、β-谷甾醇（10）和胡萝卜苷（11）。