Sun Yong-Jian, Hu Yan-Jun, Jin Dan, Li Jian-Wei, Yu Bin
Department of Traum Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Asian Pac J Cancer Prev. 2012;13(7):3099-102. doi: 10.7314/apjcp.2012.13.7.3099.
We conducted the present study to assess health-related quality of life (HRQoL) among bone cancer patients after surgical treatment in one large teaching hospitals in China, and assess the risk factors for improving the physical or mental HRQoL.
344 eligible adult patients who were admitted to the hospital with malignant bone tumors during the period of Jun. 2008 to Dec. 2011, and a reference group with 361 health cases was recruited in the same hospital during the same period. All 344 patients were followed up for one year. The HRQoL before treatment and after one year was evaluated with the Medical Outcome Short Form 36 (SF-36).
All 8 domains of HRQoL had the lowest scores greatly improved over the first year after discharge. However, the patients still had significantly lower scores in every domain than the reference group one year after discharge. Age and type of surgery were associated with HRQoL in the mental domain.
The HRQoL of patients with malignant bone tumors greatly improved one year after the treatment. This study also highlighted the utility of HRQoL assessment for prognostic evaluation of patients after surgical treatment for bone cancer.
我们开展本研究以评估中国一家大型教学医院中接受手术治疗的骨癌患者的健康相关生活质量（HRQoL），并评估改善身体或心理HRQoL的风险因素。
选取2008年6月至2011年12月期间因恶性骨肿瘤入院的344例符合条件的成年患者，并在同一医院同期招募了361例健康对照组成的参照组。对所有344例患者进行了为期一年的随访。采用医学结局简表36（SF - 36）评估治疗前及治疗一年后的HRQoL。
HRQoL的所有8个领域在出院后的第一年得分均有显著提高，尽管仍处于较低水平。然而，出院一年后，患者在各个领域的得分仍显著低于参照组。年龄和手术类型与心理领域的HRQoL相关。
恶性骨肿瘤患者的HRQoL在治疗一年后有显著改善。本研究还强调了HRQoL评估在骨癌手术治疗后患者预后评估中的作用。
