University of Calgary and Calgary Laboratory Services, Calgary, AB, Canada.
Br J Haematol. 2012 Nov;159(4):454-61. doi: 10.1111/bjh.12042. Epub 2012 Sep 21.
T-lymphoblastic leukaemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms derived from immature lymphoid cells of T-cell lineage. These neoplasms are biologically similar, but significant differences may exist between the two given their clinical differences. Although ample data regarding the immunophenotypic characterization T-ALL are available, there is a paucity of such data in children and adolescents with T-LBL. We used flow cytometry and/or immunohistochemistry to characterize the immunophenotypic profile of 180 children and adolescents with newly diagnosed T-LBL enrolled in the Children's Oncology Group 5971 study. Multiple T-cell, B-cell, myeloid, and other markers were evaluated. We identified diagnostically useful immunophenotypic features of T-LBL as well as distinct immunophenotypic subgroups, although none of these was statistically related to event-free or overall survival in this retrospective analysis. Further studies of biologically and immunophenotypically distinct subgroups of T-LBL, such as the early T-cell precursor phenotype, are warranted.
T 细胞淋巴母细胞白血病（T-ALL）和 T 细胞淋巴母细胞淋巴瘤（T-LBL）是来源于 T 细胞谱系未成熟淋巴细胞的肿瘤。这些肿瘤在生物学上相似，但由于其临床差异，两者之间可能存在显著差异。尽管关于 T-ALL 的免疫表型特征有大量数据，但儿童和青少年 T-LBL 的相关数据却很少。我们使用流式细胞术和/或免疫组织化学方法来描述 180 例新诊断的 T-LBL 患儿和青少年的免疫表型特征，这些患儿和青少年均参与了儿童肿瘤组 5971 研究。评估了多种 T 细胞、B 细胞、髓样细胞和其他标记物。我们确定了 T-LBL 的诊断有用的免疫表型特征以及独特的免疫表型亚组，但在这项回顾性分析中，这些特征与无事件生存或总生存均无统计学关联。进一步研究 T-LBL 的生物学和免疫表型上不同的亚组，如早期 T 细胞前体表型，是有必要的。
