C. Annweiler, MD, PhD, Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933 Angers Cedex 9, France; E-mail:
J Nutr Health Aging. 2014 Mar;18(3):323-9. doi: 10.1007/s12603-013-0412-1.
High arterial pulse pressure is a predictor of cardiovascular morbimortality. Mineral metabolism has been associated with blood pressure regulation. Our objective was to determine which variable among serum calcium, parathyroid hormone and 25-hydroxyvitamin D concentrations, was associated with pulse pressure among older adults.
Cross-sectional study corresponding to the baseline assessment of the EPIDOS study.
Five French cities including Amiens, Lyon, Montpellier, Paris and Toulouse.
Randomized sample of 610 community-dwelling older women (mean age 80.2±3.5years) using no antihypertensive drugs.
Serum calcium, parathyroid hormone and 25-hydroxyvitamin D concentrations; supine pulse pressure after 15 minutes of rest (hypertension defined as pulse pressure >50mmHg). Age, body mass index, the number of morbidities and of drugs daily taken, diabetes mellitus, dysthyroidy, the use of estrogenic drugs, smoking, alcohol consumption, practice of a regular physical activity, creatinine clearance, and the effects of season and study centers were used as potential confounders.
Hypertensive participants (n=539) had higher calcium concentrations than normotensive ones (94.33±4.12mg/L versus 93.28±3.36mg/L respectively, P=0.040). There were no between-group differences for serum parathyroid hormone and 25-hydroxyvitamin D concentrations. The multiple logistic regressions examining the serum calcium, parathyroid hormone and 25-hydroxyvitamin D concentrations as predictors of hypertension found an association only with calcium (adjusted odds ratio=1.19, P=0.015), but not with parathyroid hormone (adjusted OR=1.01, P=0.349) or 25-hydroxyvitamin D concentration (adjusted OR=0.99, P=0.971).
Increased serum calcium concentration was independently and positively associated with high pulse pressure in our study, possibly due to increased arterial stiffness. Interventions aimed at normalizing calcaemia may be attractive to prevent hypertension and cardiovascular risk in older adults.
高动脉脉压是心血管发病率和死亡率的预测因子。矿物质代谢与血压调节有关。我们的目的是确定血清钙、甲状旁腺激素和 25-羟维生素 D 浓度中哪个变量与老年人的脉压有关。
EPIDOS 研究的基线评估的横断面研究。
包括亚眠、里昂、蒙彼利埃、巴黎和图卢兹在内的五个法国城市。
随机抽取 610 名无抗高血压药物的社区居住的老年女性（平均年龄 80.2±3.5 岁）。
血清钙、甲状旁腺激素和 25-羟维生素 D 浓度；仰卧位休息 15 分钟后的脉压（脉压>50mmHg 定义为高血压）。年龄、体重指数、每日服用的药物数量、糖尿病、甲状腺功能减退、雌激素药物的使用、吸烟、饮酒、定期体育锻炼、肌酐清除率，以及季节和研究中心的影响被用作潜在的混杂因素。
高血压参与者（n=539）的钙浓度高于正常血压者（分别为 94.33±4.12mg/L 和 93.28±3.36mg/L，P=0.040）。血清甲状旁腺激素和 25-羟维生素 D 浓度在两组间无差异。检查血清钙、甲状旁腺激素和 25-羟维生素 D 浓度作为高血压预测因子的多元逻辑回归仅发现与钙有关（调整后的优势比=1.19，P=0.015），而与甲状旁腺激素（调整后的 OR=1.01，P=0.349）或 25-羟维生素 D 浓度（调整后的 OR=0.99，P=0.971）无关。
在我们的研究中，血清钙浓度的增加与高脉压独立且呈正相关，这可能是由于动脉僵硬增加所致。旨在使血钙正常化的干预措施可能有助于预防老年人的高血压和心血管风险。
