Biophys J. 2012 Sep 19;103(6):L31-3. doi: 10.1016/j.bpj.2012.08.019.
The bacterial chemotaxis network features robust adaptation implemented by negative integral feedback. Here, we show that the adaptation module can be characterized by measurement of the response to simple step-addition and removal of a chemoattractant. The method does not rely on a particular form of the receptor module, and thus can be used to characterize other integral feedback networks.
细菌趋化作用网络具有通过负积分反馈实现的强大适应性。在这里,我们表明,适应模块可以通过测量对简单的化学引诱物添加和去除的响应来进行特征描述。该方法不依赖于受体模块的特定形式,因此可以用于描述其他积分反馈网络。