Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Invest Ophthalmol Vis Sci. 2012 Oct 17;53(11):7194-200. doi: 10.1167/iovs.12-9726.
To investigate the association between the distribution profile of the retinal nerve fiber layer (RNFL) bundles and myopia and its impact on interpretation of the RNFL map imaged by a spectral-domain optical coherence tomography (SD-OCT).
the RNFL of 189 myopic eyes from 103 normal healthy myopic participants was imaged by an SD-OCT. The angle between the long axes of the superotemporal and inferotemporal RNFL bundles determined in the RNFL thickness map (the RNFL distribution angle) and the abnormal area in the RNFL thickness deviation map were measured. The associations between the RNFL distribution angle and the axial length/spherical error, and between the area of abnormal RNFL measurement and each of the following: axial length, spherical error, RNFL distribution angle, average RNFL thickness, optic disc area, and signal strength were analyzed with linear mixed models.
The RNFL distribution angle decreased with the axial length (P < 0.011). In the univariate analysis, the area of abnormal RNFL measurement was positively associated with the axial length (P = 0.001); and negatively associated with the RNFL distribution angle (P < 0.001), average RNFL thickness (P < 0.001), optic disc area (P ≤ 0.001), and signal strength (P = 0.026). In the multivariate analysis, the area of abnormal RNFL measurement was negatively associated with the RNFL distribution angle independent of other covariates.
The superotemporal and inferotemporal RNFL bundles converged temporally with increasing myopia, which was associated with an increase in area of abnormal RNFL measurement. The interpretation of the RNFL thickness map in myopic eyes requires careful consideration of the distribution pattern of the RNFL bundles.
研究视网膜神经纤维层（RNFL）束的分布与近视的关系及其对视神经 OCT 图像中 RNFL 图的解读的影响。
对 103 名正常近视者的 189 只近视眼进行了 SD-OCT 成像。在 RNFL 厚度图上测量超颞侧和颞下侧 RNFL 束长轴之间的夹角（RNFL 分布角）和 RNFL 厚度偏差图上的异常区域。采用线性混合模型分析 RNFL 分布角与眼轴长度/球镜误差之间的关系，以及异常 RNFL 测量面积与眼轴长度、球镜误差、RNFL 分布角、平均 RNFL 厚度、视盘面积和信号强度之间的关系。
RNFL 分布角随眼轴长度的增加而减小（P<0.011）。在单变量分析中，异常 RNFL 测量面积与眼轴长度呈正相关（P=0.001），与 RNFL 分布角（P<0.001）、平均 RNFL 厚度（P<0.001）、视盘面积（P≤0.001）和信号强度（P=0.026）呈负相关。在多变量分析中，异常 RNFL 测量面积与 RNFL 分布角呈负相关，与其他协变量无关。
随着近视的增加，超颞侧和颞下侧 RNFL 束在时间上趋于汇聚，这与异常 RNFL 测量面积的增加有关。在近视眼中，RNFL 厚度图的解读需要仔细考虑 RNFL 束的分布模式。
