Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
J Oncol. 2012;2012:370481. doi: 10.1155/2012/370481. Epub 2012 Sep 10.
Epidemiological studies have demonstrated the cancer protective effects of dietary agents and other natural compounds isolated from fruits, soybeans, and vegetables on neoplasia. Studies have also revealed the potential for these natural products to be combined with chemotherapy or radiotherapy for the more effective treatment of cancer. In this paper we discuss the potential for targeting the DNA base excision repair enzyme APE1/Ref-1 using dietary agents such as soy isoflavones, resveratrol, curcumin, and the vitamins ascorbate and α-tocopherol. We also discuss the potential role of soy isoflavones in sensitizing cancer cells to the effects of radiotherapy. A comprehensive review of the dual nature of APE1/Ref-1 in DNA repair and redox activation of cellular transcription factors, NF-κB and HIF-1α, is also discussed. Further research efforts dedicated to delineating the role of APE1/Ref-1 DNA repair versus redox activity in sensitizing cancer cells to conventional treatment are warranted.
流行病学研究表明，膳食因子和其他天然化合物可预防肿瘤发生，这些因子和天然化合物来自水果、大豆和蔬菜。这些天然产物也具有与化疗或放疗联合应用的潜力，以提高癌症的治疗效果。本文讨论了使用膳食因子如大豆异黄酮、白藜芦醇、姜黄素、抗坏血酸和α-生育酚来靶向 DNA 碱基切除修复酶 APE1/Ref-1 的可能性。我们还讨论了大豆异黄酮在增强癌细胞对放射治疗的敏感性方面的潜在作用。本文还全面讨论了 APE1/Ref-1 在 DNA 修复和细胞转录因子 NF-κB 和 HIF-1α 的氧化还原激活中的双重作用。有必要进行进一步的研究工作，以阐明 APE1/Ref-1 在 DNA 修复和氧化还原活性方面的作用，以增强癌细胞对常规治疗的敏感性。
