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丁香精油及其两种活性成分对苹果汁致牙齿脱矿的体外抑制作用。

In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice.

作者信息

Marya Charu M, Satija Gunjan, J Avinash, Nagpal Ruchi, Kapoor Rohtash, Ahmad Aijaz

机构信息

Department of Public Health Dentistry, Sudha Rustagi College of Dental Sciences and Research, Faridabad, Haryana, India.

出版信息

Int J Dent. 2012;2012:759618. doi: 10.1155/2012/759618. Epub 2012 Aug 21.

DOI:10.1155/2012/759618
PMID:22997520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3432374/
Abstract

The dental erosion or decalcification of enamel is a significant clinical problem. Apple acidic beverages are thought to increase the potential for dental erosion. The purpose of this in vitro study was to investigate the effect of clove essential oil (CEO) and its active principles on tooth decalcification of apple juices. On GC-MS analysis, CEO showed a high content of eugenol (58.29%) and eugenyl acetate (19.10%). Teeth specimens were randomly divided into 5 treatment groups: control, CEO, eugenol, eugenyl-acetate, and fluoride. The specimens were exposed for 24 h and were analyzed for calcium contents using Inductively Coupled Plasma with Optical Emission Spectroscopy (ICP-OES). Data were analyzed using student t-test (P < 0.05). CEO, eugenol, and eugenyl-acetate significantly decreased the decalcification of tooth by the apple juice to only 17, 24, and 21 mgL(-1), respectively. Hemolytic activity on human erythrocytes was studied to exclude the possibility of further associated cytotoxicity. It was observed that the CEO and its two lead molecules inhibit the decalcification and/or promote the remineralization caused by the apple juices. The effect of the test compounds appears to be distinct like that of fluoride treatment. CEO may, therefore, serve to be a promising adjunct to fluoride in the treatment of root caries during minimally invasive therapy.

摘要

牙釉质的酸蚀或脱矿是一个严重的临床问题。苹果酸性饮料被认为会增加牙釉质酸蚀的可能性。本体外研究的目的是调查丁香精油（CEO）及其活性成分对苹果汁导致的牙齿脱矿的影响。通过气相色谱-质谱联用（GC-MS）分析，CEO显示出高含量的丁香酚（58.29%）和乙酸丁香酚酯（19.10%）。牙齿标本被随机分为5个处理组：对照组、CEO组、丁香酚组、乙酸丁香酚酯组和氟化物组。标本暴露24小时，然后使用电感耦合等离子体发射光谱仪（ICP-OES）分析钙含量。数据采用学生t检验进行分析（P<0.05）。CEO、丁香酚和乙酸丁香酚酯分别将苹果汁导致的牙齿脱矿显著降低至仅17、24和21mg/L。研究了对人红细胞的溶血活性，以排除进一步相关细胞毒性的可能性。观察到CEO及其两个主要分子抑制了苹果汁导致的脱矿和/或促进了再矿化。测试化合物的效果似乎与氟化物治疗不同。因此，在微创治疗期间，CEO可能成为氟化物治疗根龋的一种有前景的辅助手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/3432374/ea6b9980c907/IJD2012-759618.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/3432374/03c7740e59c3/IJD2012-759618.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/3432374/3e2ec3cf2313/IJD2012-759618.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/3432374/ea6b9980c907/IJD2012-759618.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/3432374/03c7740e59c3/IJD2012-759618.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/3432374/3e2ec3cf2313/IJD2012-759618.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9706/3432374/ea6b9980c907/IJD2012-759618.003.jpg

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