Abd El Khalek Karima A, El Seify Magda Y, Youssef Omneya I, Badr Mona M
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11321, Egypt.
ISRN Pediatr. 2012;2012:859873. doi: 10.5402/2012/859873. Epub 2012 Sep 11.
Chronic airways infection and inflammation are leading causes of morbidity and mortality in chronic lung diseases (CLD). Pulmonary exacerbations are major causes of morbidity in CLD. Exhaled carbon monoxide (eCO) is a product of endogenous metabolic processes whose presence in exhaled breath is considered an index of inflammatory processes. Objective. To evaluate carbon monoxide (eCO) as inflammatory marker for early detection of acute exacerbation in CLD. Methods. Case control study included 40 children with CLD (twenty in exacerbation, group I and twenty in quiescent period, group II) recruited from the Chest Clinic, Children's Hospital, Ain Shams University. Twenty apparently healthy children were included as controls (group III). Results. Patients' mean age was 9.98 ± 3.29 years: 24 (60%) males and 16 (40%) females. The mean eCO level among patients during exacerbation was 5.35 ± 1.35 (ppm) compared to 2.65 ± 0.49 (ppm) in quiescent stage and 1.30 ± 0.47 (ppm) in controls. eCO cutoff value discriminating cases and control was 1.5 (ppm) (sensitivity; 100% and specificity 70%) and cutoff value discriminating group I from group II was 3 (ppm) (sensitivity: 100% and specificity: 100%). Conclusion. Exhaled CO can be considered a noninvasive early marker of acute exacerbation of CLD.
慢性气道感染和炎症是慢性肺部疾病（CLD）发病和死亡的主要原因。肺部急性加重是CLD发病的主要原因。呼出一氧化碳（eCO）是内源性代谢过程的产物，其在呼出气体中的存在被认为是炎症过程的指标。目的：评估一氧化碳（eCO）作为CLD急性加重早期检测的炎症标志物。方法：病例对照研究纳入了从艾因夏姆斯大学儿童医院胸科诊所招募的40名CLD儿童（20名处于急性加重期，为I组；20名处于静止期，为II组）。另外纳入20名明显健康的儿童作为对照组（III组）。结果：患者的平均年龄为9.98±3.29岁：男性24名（60%），女性16名（40%）。急性加重期患者的平均eCO水平为5.35±1.35（ppm），而静止期为2.65±0.49（ppm），对照组为1.30±0.47（ppm）。区分病例和对照组的eCO临界值为1.5（ppm）（敏感性为100%，特异性为70%），区分I组和II组的临界值为3（ppm）（敏感性为100%，特异性为100%）。结论：呼出CO可被视为CLD急性加重的非侵入性早期标志物。
