Department of Pulmonology, National Koranyi Institute for Pulmonology, Budapest, Hungary.
J Breath Res. 2010 Dec;4(4):047102. doi: 10.1088/1752-7155/4/4/047102. Epub 2010 Nov 30.
Breath tests have gained increasing interest in recent years mainly driven by the unmet clinical need to monitor airway diseases and to obtain information of unravelled aspects of respiratory disorders. Carbon monoxide is present in the exhaled breath and has been suggested to reflect ongoing oxidative stress, even if there are some confounding factors limiting its clinical usefulness. Increased concentration of exhaled carbon monoxide has been demonstrated in different acute and chronic airway diseases including allergic rhinitis, asthma, bronchiectasis, and post transplant bronchiolitis obliterans syndrome. Although exhaled carbon monoxide might not prove as a clinically useful biomarker of airway diseases, its measurement has helped to understand the place of heme oxygenase activity in allergic and non-allergic airway diseases. The scope of this review is the exciting field of exhaled carbon monoxide in airway diseases.
近年来，呼气测试受到越来越多的关注，主要是因为临床需要监测气道疾病并获取呼吸系统疾病未被揭示的方面的信息。一氧化碳存在于呼出的气体中，被认为反映了持续的氧化应激，尽管存在一些限制其临床应用的混杂因素。在不同的急性和慢性气道疾病中，包括过敏性鼻炎、哮喘、支气管扩张和移植后细支气管炎闭塞综合征，已经证明呼出的一氧化碳浓度增加。尽管呼出的一氧化碳可能不能证明是气道疾病的一种有用的临床生物标志物，但它的测量有助于了解血红素加氧酶活性在过敏性和非过敏性气道疾病中的作用。本文综述了气道疾病中令人兴奋的呼气一氧化碳领域。
