Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey.
Curr Drug Deliv. 2013 Feb;10(1):71-5. doi: 10.2174/1567201811310010013.
Recent studies suggest that overproduction of reactive oxygen and nitrogen species (ROS/RNS), lowered antioxidant defense of the body. Oxidative stress is damaging to DNA, lipids, proteins and many more vital macromolecules. Consequences of oxidative stress thought to contribute to the development of a wide range of diseases including Alzheimer's disease, Parkinson's disease, diabetes, rheumatoid arthritis, neurodegeneration in motor neuron diseases and many cancer types. Melatonin (MLT) is a powerful antioxidant with a particular role in the protection of nuclear and mitochondrial DNA. To find an improved antioxidant activity, developments of novel synthetic analogues are under investigation. These studies may offer a new progress and approach in antioxidant drug development as well as antioxidant chemistry. Therefore, we have been synthesizing novel MLT derivatives and investigating their antioxidant capacities. This review gives a brief knowledge about the MLT based analogue indole derivatives as potential antioxidants.
最近的研究表明，活性氧和氮物种（ROS/RNS）的过度产生，降低了身体的抗氧化防御能力。氧化应激对 DNA、脂质、蛋白质和许多其他重要的生物大分子都有损害。氧化应激的后果被认为有助于多种疾病的发展，包括阿尔茨海默病、帕金森病、糖尿病、类风湿性关节炎、运动神经元疾病中的神经退行性变和许多癌症类型。褪黑素（MLT）是一种强大的抗氧化剂，在保护核和线粒体 DNA 方面具有特殊作用。为了寻找改善的抗氧化活性，新型合成类似物的开发正在研究中。这些研究可能为抗氧化药物开发以及抗氧化化学提供新的进展和方法。因此，我们一直在合成新型 MLT 衍生物，并研究它们的抗氧化能力。这篇综述简要介绍了基于 MLT 的吲哚衍生物作为潜在抗氧化剂的知识。
