Gurer-Orhan Hande, Suzen Sibel
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey.
Curr Med Chem. 2015;22(4):490-9. doi: 10.2174/0929867321666141215095259.
It is known that melatonin (MLT) and some of its metabolites act as antioxidants by scavenging free radicals as well as increasing the activity of antioxidant enzymes in the body. MLT is suggested to exert beneficial effects via various mechanisms in the treatment of many diseases, such as cancer, neurodegenerative diseases, epilepsy, diabetes mellitus and obesity. People working in nightshift exhibit decreased MLT levels that are suggested to be related with increased risk of hormone-related diseases. Similarly blind people were found to have increased MLT levels protecting against many diseases. This review briefly summarizes the published reports supporting these beneficial effects of MLT. Furthermore the present review involves recent developments related to the antioxidant effect of remarkable and multi-faceted molecule MLT as well as its metabolites and its synthesized analogues. The role of MLT as an inhibitor of bioactivation reactions is also discussed.
已知褪黑素（MLT）及其某些代谢产物可通过清除自由基以及提高体内抗氧化酶的活性来发挥抗氧化作用。MLT被认为可通过多种机制对许多疾病的治疗产生有益影响，如癌症、神经退行性疾病、癫痫、糖尿病和肥胖症。从事夜班工作的人MLT水平降低，这被认为与激素相关疾病风险增加有关。同样，发现盲人的MLT水平升高，可预防多种疾病。本综述简要总结了支持MLT这些有益作用的已发表报告。此外，本综述还涉及与显著且多面的分子MLT及其代谢产物和合成类似物的抗氧化作用相关的最新进展。还讨论了MLT作为生物活化反应抑制剂的作用。
