Department of Molecular Medicine, University of Padova, Padova, Italy.
Clin Microbiol Infect. 2012 Dec;18(12):E541-4. doi: 10.1111/1469-0691.12001. Epub 2012 Sep 25.
During 2008-2009, several human cases of WNV disease caused by an endemic lineage 1a strain were reported in areas surrounding the Po river in north-eastern Italy. Since 2010, cases have been recorded in nearby northern areas, where, in 2011, both lineage 1a and 2 were detected. We describe here two new WNV complete genome sequences from human cases of WNV infection occurring in 2011 in the Veneto Region. Phylogenetic analysis showed that both genome sequences belonged to lineage 1a and were related to WNV strains of the Western Mediterranean subtype. The novel WNV genomes had high nucleotide and amino acid sequence divergence from each other and from the WNV strain circulating in Italy in 2008-2009. The presence of different WNV strains in a relatively small geographical area is a novel finding with unpredictable impact on human disease that requires further investigation.
在 2008-2009 年期间，意大利东北部波河沿岸地区报告了几例由地方性 1a 谱系株引起的西尼罗河病毒病人类病例。自 2010 年以来，在附近的北部地区也有病例记录，2011 年在这些地区同时检测到了 1a 谱系和 2 谱系。本文描述了 2011 年威尼托地区发生的西尼罗河病毒感染人类病例的两个新的西尼罗河病毒完整基因组序列。系统进化分析表明，这两个基因组序列均属于 1a 谱系，与西地中海亚型的西尼罗河病毒株有关。新型西尼罗河病毒基因组与意大利 2008-2009 年流行的病毒株之间存在较高的核苷酸和氨基酸序列差异。在相对较小的地理区域内存在不同的西尼罗河病毒株是一个新的发现，对人类疾病具有不可预测的影响，需要进一步研究。
