Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), Hospital Virgen del Rocio, 41013 Sevilla, Spain.
Computational Systems Medicine, Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, 41013 Sevilla, Spain.
Viruses. 2021 May 5;13(5):836. doi: 10.3390/v13050836.
During recent decades West Nile Virus (WNV) outbreaks have continuously occurred in the Mediterranean area. In August 2020 a new WNV outbreak affected 71 people with meningoencephalitis in Andalusia and six more cases were detected in Extremadura (south-west of Spain), causing a total of eight deaths. The whole genomes of four viruses were obtained and phylogenetically analyzed in the context of recent outbreaks. The Andalusian viral samples belonged to lineage 1 and were relatively similar to those of previous outbreaks which occurred in the Mediterranean region. Here we present a detailed analysis of the outbreak, including an extensive phylogenetic study. As part on this effort, we implemented a local Nextstrain server, which has become a constituent piece of regional epidemiological surveillance, wherein forthcoming genomes of environmental samples or, eventually, future outbreaks, will be included.
在最近几十年里，西尼罗河病毒（WNV）爆发不断在地中海地区发生。2020 年 8 月，一场新的 WNV 爆发影响了安达卢西亚的 71 人，其中包括脑膜炎，在埃斯特雷马杜拉（西班牙西南部）还检测到了另外 6 例病例，共造成 8 人死亡。获得了 4 种病毒的全基因组，并在最近爆发的背景下进行了系统进化分析。安达卢西亚的病毒样本属于谱系 1，与之前在地中海地区发生的爆发的病毒样本相对相似。在这里，我们详细分析了此次爆发，包括广泛的系统进化研究。作为这项工作的一部分，我们实施了一个本地 Nextstrain 服务器，这已成为区域流行病学监测的一个组成部分，其中包括环境样本的即将到来的基因组，或者未来的爆发。
