己酮可可碱与环孢素治疗发热性溃疡性坏死性穆查-哈伯曼病

Pentoxifylline and cyclosporine in the treatment of febrile ulceronecrotic Mucha-Habermann disease.

作者信息

Uzoma Miranda A, Wilkerson Michael G, Carr Vicki L, Westhoven Gail S, Raimer Sharon A S

机构信息

Medical student, School of Medicine, University of Texas Medical Branch, Galveston, TexasDepartment of Dermatology, University of Texas Medical Branch, Galveston, TexasSpring Dermatology, Spring, TexasAssociated Dermatologists, Birmingham, Alabama.

出版信息

Pediatr Dermatol. 2014 Jul-Aug;31(4):525-7. doi: 10.1111/j.1525-1470.2012.01862.x. Epub 2012 Sep 25.

DOI:10.1111/j.1525-1470.2012.01862.x

PMID:23005254

Abstract

We describe two pediatric cases of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) with response to pentoxifylline and cyclosporine therapies. Based on our review of the literature, we are presenting the first case of FUMHD treated with pentoxifylline and the third case of FUMHD successfully treated with cyclosporine. These agents may be of therapeutic benefit in the treatment of FUMHD, in part by suppressing tumor necrosis factor-alpha, which we believe may mediate the disease process.

摘要

我们描述了两例对己酮可可碱和环孢素治疗有反应的小儿发热性溃疡性坏死性穆查-哈伯曼病（FUMHD）病例。基于我们对文献的回顾，我们呈现了首例用己酮可可碱治疗的FUMHD病例以及第三例用环孢素成功治疗的FUMHD病例。这些药物可能对FUMHD的治疗有益，部分原因是通过抑制肿瘤坏死因子-α，我们认为该因子可能介导了疾病进程。