Reuter I, Mehnert S, Sammer G, Oechsner M, Engelhardt M
Department of Neurology, Justus-Liebig University, Klinikstraße 33, 35392 Giessen, Germany.
J Aging Res. 2012;2012:235765. doi: 10.1155/2012/235765. Epub 2012 Sep 12.
Mild cognitive impairment, especially executive dysfunction might occur early in the course of Parkinson's disease. Cognitive training is thought to improve cognitive performance. However, transfer of improvements achieved in paper and pencil tests into daily life has been difficult. The aim of the current study was to investigate whether a multimodal cognitive rehabilitation programme including physical exercises might be more successful than cognitive training programmes without motor training. 240 PD-patients were included in the study and randomly allocated to three treatment arms, group A cognitive training, group B cognitive training and transfer training and group C cognitive training, transfer training and psychomotor and endurance training. The primary outcome measure was the ADAS-Cog. The secondary outcome measure was the SCOPA-Cog. Training was conducted for 4 weeks on a rehabilitation unit, followed by 6 months training at home. Caregivers received an education programme. The combination of cognitive training using paper and pencil and the computer, transfer training and physical training seems to have the greatest effect on cognitive function. Thus, patients of group C showed the greatest improvement on the ADAS-Cog and SCOPA-COG and were more likely to continue with the training programme after the study.
轻度认知障碍，尤其是执行功能障碍可能在帕金森病病程早期出现。认知训练被认为可以改善认知表现。然而，纸笔测试中取得的进步转化到日常生活中却很困难。本研究的目的是调查包括体育锻炼在内的多模式认知康复计划是否比没有运动训练的认知训练计划更成功。240名帕金森病患者被纳入研究，并随机分配到三个治疗组，A组为认知训练组，B组为认知训练和转移训练组，C组为认知训练、转移训练以及心理运动和耐力训练组。主要结局指标是阿尔茨海默病评估量表认知部分（ADAS-Cog）。次要结局指标是帕金森病认知功能评定量表（SCOPA-Cog）。训练在康复单元进行4周，随后在家中进行6个月训练。照顾者接受了一个教育项目。使用纸笔和计算机进行的认知训练、转移训练和体育训练相结合似乎对认知功能有最大影响。因此，C组患者在ADAS-Cog和SCOPA-COG上改善最大，并且在研究结束后更有可能继续参加训练项目。
