Headquarters, Chemo-Sero-Therapeutic Research Institute Kaketsuken, Kumamoto 860-8568, Japan.
Microbiol Immunol. 2012 Dec;56(12):810-6. doi: 10.1111/j.1348-0421.2012.00511.x.
The cross-reactivity of antibody to the swine-origin pandemic influenza A (H1N1) 2009 virus induced by vaccination with a seasonal trivalent influenza vaccine was studied. Paired sera from a cohort of adult volunteers vaccinated with a trivalent seasonal influenza vaccine every year from 2006 to 2008 were collected each year and tested by hemagglutination inhibition (HI) for antibody against the pandemic influenza A (H1N1) 2009 virus. There was little increase in the geometric mean titer overall; a slight increase was detected in the sera obtained in the 2007-2008 season but not in the other two seasons. The proportion of individuals with HI antibody titers ≥ 1:40 did not change significantly from year to year. These results indicate that cross-reactivity of the antibodies induced by a trivalent seasonal vaccine to the pandemic influenza A (H1N1) 2009 virus is marginal.
研究了接种季节性三价流感疫苗诱导的针对猪源大流行性流感 A（H1N1）2009 病毒的抗体的交叉反应性。每年从 2006 年至 2008 年用三价季节性流感疫苗对一组成年志愿者进行疫苗接种，并通过血凝抑制（HI）试验对大流行性流感 A（H1N1）2009 病毒的抗体进行检测。总体而言，抗体几何平均滴度增加很少；在 2007-2008 季节获得的血清中检测到略有增加，但在其他两个季节则没有增加。HI 抗体滴度≥1：40 的个体比例每年没有明显变化。这些结果表明，三价季节性疫苗诱导的针对大流行性流感 A（H1N1）2009 病毒的抗体的交叉反应性很小。
