JMI Laboratories, North Liberty, IA 52317, USA.
Diagn Microbiol Infect Dis. 2013 Jan;75(1):107-9. doi: 10.1016/j.diagmicrobio.2012.08.024. Epub 2012 Sep 23.
A 14-year longitudinal survey of Streptococcus pneumoniae (18,911) strains by the SENTRY Antimicrobial Surveillance Program shows significant increases in resistance to amoxicillin/clavulanate (18.9%), penicillin at a MIC of ≥ 4 μg/mL (14.8%), and ceftriaxone (11.7%) among 2011 isolates. Fluoroquinolones (levofloxacin; 98.8% susceptible) and ceftaroline (99.1-100.0% susceptible depending on breakpoint criteria) exhibited high levels of potency, as did linezolid, tigecycline, and vancomycin (100.0%). In summary, resistance rates to several antimicrobials continue to rise after introductions of both pneumococcal conjugate vaccines, as noted from these results for 1998 through 2011.
SENTRY 抗菌药物监测计划对 18911 株肺炎链球菌进行了 14 年的纵向研究，结果显示，2011 年分离株对阿莫西林/克拉维酸（18.9%）、青霉素 MIC≥4μg/ml（14.8%）和头孢曲松（11.7%）的耐药性显著增加。氟喹诺酮类药物（左氧氟沙星；敏感率 98.8%）和头孢洛林（根据折点标准，敏感率为 99.1-100.0%）显示出很高的效力，利奈唑胺、替加环素和万古霉素（100.0%）也是如此。总之，这些结果表明，自 1998 年至 2011 年，在两种肺炎球菌结合疫苗推出后，几种抗菌药物的耐药率持续上升。
