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Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01555-17. Print 2018 Feb.
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本文引用的文献

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Genomic Epidemiology of Penicillin-Nonsusceptible Pneumococci with Nonvaccine Serotypes Causing Invasive Disease in the United States.美国非疫苗血清型青霉素不敏感肺炎球菌引起侵袭性疾病的基因组流行病学
J Clin Microbiol. 2017 Apr;55(4):1104-1115. doi: 10.1128/JCM.02453-16. Epub 2017 Jan 18.
2
Ceftaroline Activity Against Multidrug-Resistant Streptococcus pneumoniae from U.S. Medical Centers (2014) and Molecular Characterization of a Single Ceftaroline Nonsusceptible Isolate.头孢洛林对来自美国医疗中心的耐多药肺炎链球菌的活性（2014年）以及一株对头孢洛林不敏感菌株的分子特征分析
Microb Drug Resist. 2017 Jul;23(5):571-579. doi: 10.1089/mdr.2016.0258. Epub 2016 Dec 5.
3
Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007-13.2007 - 2013年加拿大耐多药和广泛耐药肺炎链球菌的特征分析
J Antimicrob Chemother. 2015 Aug;70(8):2199-202. doi: 10.1093/jac/dkv107. Epub 2015 Apr 28.
4
Changes in pneumococcal serotypes and antimicrobial resistance after introduction of the 13-valent conjugate vaccine in the United States.美国引入13价结合疫苗后肺炎球菌血清型及抗菌药物耐药性的变化
Antimicrob Agents Chemother. 2014 Nov;58(11):6484-9. doi: 10.1128/AAC.03344-14. Epub 2014 Aug 18.
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Serotype distribution and antimicrobial susceptibility of USA Streptococcus pneumoniae isolates collected prior to and post introduction of 13-valent pneumococcal conjugate vaccine.13价肺炎球菌结合疫苗引入前后收集的美国肺炎链球菌分离株的血清型分布及抗菌药物敏感性
Diagn Microbiol Infect Dis. 2014 Sep;80(1):19-25. doi: 10.1016/j.diagmicrobio.2014.05.020. Epub 2014 May 24.
6
Decreased ceftriaxone susceptibility in emerging (35B and 6C) and persisting (19A) Streptococcus pneumoniae serotypes in the United States, 2011-2012: ceftaroline remains active in vitro among β-lactam agents.2011 - 2012年美国新出现的（35B和6C）及持续存在的（19A）肺炎链球菌血清型中头孢曲松敏感性降低：头孢洛林在β - 内酰胺类药物中体外仍保持活性。
Antimicrob Agents Chemother. 2014 Aug;58(8):4923-7. doi: 10.1128/AAC.02976-14. Epub 2014 May 27.
7
Antimicrobial activity of ceftaroline tested against drug-resistant subsets of Streptococcus pneumoniae from U.S. medical centers.在美国医疗中心对肺炎链球菌耐药亚群进行测试时头孢洛林的抗菌活性。
Antimicrob Agents Chemother. 2014;58(4):2468-71. doi: 10.1128/AAC.02557-13. Epub 2014 Feb 10.
8
Ceftaroline fosamil: a review of its use in the treatment of complicated skin and soft tissue infections and community-acquired pneumonia.头孢洛林酯：在治疗复杂性皮肤和软组织感染及社区获得性肺炎中的应用评价。
Drugs. 2013 Jul;73(10):1067-94. doi: 10.1007/s40265-013-0075-6.
9
Update on antimicrobial susceptibility trends among Streptococcus pneumoniae in the United States: report of ceftaroline activity from the SENTRY Antimicrobial Surveillance Program (1998-2011).美国肺炎链球菌对抗菌药物敏感性趋势的最新情况：来自 SENTRY 抗菌药物监测计划（1998-2011 年）的头孢洛林活性报告。
Diagn Microbiol Infect Dis. 2013 Jan;75(1):107-9. doi: 10.1016/j.diagmicrobio.2012.08.024. Epub 2012 Sep 23.
10
In vitro activity of ceftaroline against multidrug-resistant Staphylococcus aureus and Streptococcus pneumoniae: a review of published studies and the AWARE Surveillance Program (2008-2010).头孢洛林对耐多药金黄色葡萄球菌和肺炎链球菌的体外活性：对已发表研究和 AWARE 监测计划（2008-2010 年）的回顾。
Clin Infect Dis. 2012 Sep;55 Suppl 3:S206-14. doi: 10.1093/cid/cis563.

美国医院分离的肺炎链球菌对头孢洛林及对照药物的活性：AWARE 监测项目（2010 至 2016 年）七年的结果。

Activities of Ceftaroline and Comparators against Streptococcus pneumoniae Isolates from U.S. Hospitals: Results from Seven Years of the AWARE Surveillance Program (2010 to 2016).

机构信息

JMI Laboratories, North Liberty, Iowa, USA.

University of Iowa, Iowa City, Iowa, USA.

出版信息

Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01555-17. Print 2018 Feb.

DOI:10.1128/AAC.01555-17
PMID:29158271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5786790/
Abstract

We evaluated trends in antimicrobial susceptibility in United States hospitals in the 2010 to 2016 period. A total of 8,768 clinical isolates from 47 medical centers were tested for susceptibility by broth microdilution methods. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) rates decreased from 25.7% and 12.4%, respectively, in 2010 to 17.7% and 3.6%, respectively, in 2016. The susceptibilities to most comparator antimicrobial agents increased, whereas the susceptibilities to ceftaroline, levofloxacin, linezolid, and tigecycline remained stable. Ceftaroline retained potent activity against (>99.9%) with no marked variations.

摘要

我们评估了 2010 年至 2016 年期间美国医院的抗菌药物敏感性趋势。对来自 47 个医疗中心的 8768 株临床分离株进行肉汤微量稀释法药敏试验。2010 年，耐多药（MDR）和广泛耐药（XDR）的发生率分别为 25.7%和 12.4%，到 2016 年分别下降至 17.7%和 3.6%。大多数比较抗菌药物的敏感性增加，而头孢洛林、左氧氟沙星、利奈唑胺和替加环素的敏感性保持稳定。头孢洛林对 （>99.9%）保持强效活性，无明显变化。