无过渡金属参与的烯烃与芳基重氮盐和 TEMPONa 的氧芳基化反应。
Transition-metal-free oxyarylation of alkenes with aryl diazonium salts and TEMPONa.
机构信息
Institute of Organic Chemistry, University of Münster, Corrensstrasse 40, 48149 Münster, Germany.
出版信息
J Am Chem Soc. 2012 Oct 10;134(40):16516-9. doi: 10.1021/ja307638u. Epub 2012 Sep 28.
The reaction of readily available TEMPONa with aryl diazonium salts allows for clean generation of the corresponding aryl radicals along with TEMPO. Aryl radical addition to alkenes with subsequent TEMPO trapping provides the corresponding oxyarylation products in good to excellent yields. These experimentally easy to conduct transformations occur in the absence of any transition metal under mild conditions, and the process shows broad functional group compatibility.
readily 可用的 TEMPONa 与芳基重氮盐反应，可以干净地生成相应的芳基自由基和 TEMPO。芳基自由基与烯烃加成，随后用 TEMPO 捕获，以良好到优异的收率得到相应的氧芳基化产物。这些实验操作简单的转化在温和条件下无需任何过渡金属即可进行，并且该过程显示出广泛的官能团相容性。
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