Department of Pharmaceutical Sciences, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.
Colloids Surf B Biointerfaces. 2013 Jan 1;101:350-2. doi: 10.1016/j.colsurfb.2012.06.032. Epub 2012 Jul 5.
In our previous study, the degree of adsorption of 9 representative antimicrobial agents to Toraymyxin(®) PMX-F sheets was quantitatively evaluated. As a result, the adsorption rate was 22.1% for Linezolid in the presence of serum. Therefore, we investigated whether two types of antimicrobial agents (Ciprofroxacin and Linezolid) can be better adsorbed on PMX-F sheets. When the number of PMX-F sheets was increased in a step wise manner, specifically 2, 4, 6, 8 and 12, the adsorption rate increased linearly. In addition, the adsorption to polymyxin-B immobilized fiber (Toraymyxin(®) PMX-20R) cartridges, widely used to remove endotoxins from circulating blood in the treatment of sepsis, was quantitatively evaluated. As a result, in the presence of serum, Linezolid showed adsorption to PMX-20R, and the adsorption rate after 2h was 54.5%, and that after 4h was 65.8%. The results of this study suggest the necessity of monitoring blood antimicrobial concentration during treatment for sepsis with Linezolid, which showed adsorption to PMX-20R in an environment close to a clinical environment.
在我们之前的研究中，定量评估了 9 种代表性抗菌剂对 Toraymyxin(®) PMX-F 片的吸附程度。结果表明，在有血清存在的情况下，利奈唑胺的吸附率为 22.1%。因此，我们研究了两种类型的抗菌剂（环丙沙星和利奈唑胺）是否可以更好地吸附在 PMX-F 片上。当 PMX-F 片的数量以逐步方式增加时，具体为 2、4、6、8 和 12 时，吸附率呈线性增加。此外，还定量评估了广泛用于治疗败血症以从循环血液中去除内毒素的固定化多粘菌素 B 纤维（Toraymyxin(®) PMX-20R）筒对多粘菌素的吸附作用。结果表明，在有血清存在的情况下，利奈唑胺对 PMX-20R 有吸附作用，2 小时后的吸附率为 54.5%，4 小时后的吸附率为 65.8%。本研究结果表明，在接近临床环境的环境中，利奈唑胺对 PMX-20R 有吸附作用，因此在治疗败血症时需要监测血液中抗菌药物的浓度。
