Ostrowski S R, Gunter E W, Matte T D
Division of Environmental Hazards and Health Effects, Centers for Disease Control, Atlanta, Georgia 30333.
Vet Hum Toxicol. 1990 Feb;32(1):53-6.
During the course of an investigation into community lead poisoning near a secondary lead smelter in Jamaica, blood lead and zinc protoporphyrin levels were measured in 8 exposed and 6 (3 Jamaican, 3 US) unexposed donkeys and mules. The blood lead levels of 6 animals in the contaminated area ranged from 7.5 to 33 micrograms/dl (mean = 17.6 micrograms/dl), compared to 1.8 and 2.4 in unexposed Jamaican animals. More striking was the difference in zinc protoporphyrin levels; all 8 exposed donkeys and mules had values between 900 and 1890 micrograms/dl, compared with a range of 34-46 micrograms/dl for 3 Jamaican control donkeys. These findings suggest that zinc protoporphyrin may be a useful method of screening for subclinical lead toxicity in equines.
在对牙买加一家二次铅冶炼厂附近社区铅中毒情况的调查过程中，对8头暴露于铅污染环境的驴和骡以及6头（3头牙买加的、3头美国的）未暴露的驴和骡测量了血铅和锌原卟啉水平。污染区域内6只动物的血铅水平在7.5至33微克/分升之间（平均为17.6微克/分升），而未暴露的牙买加动物血铅水平为1.8和2.4微克/分升。锌原卟啉水平的差异更为显著；所有8头暴露的驴和骡的锌原卟啉值在900至1890微克/分升之间，而3头牙买加对照驴的锌原卟啉值范围为34 - 46微克/分升。这些发现表明，锌原卟啉可能是一种筛查马属动物亚临床铅中毒的有用方法。
