Eisinger J, Blumberg W E, Fischbein A, Lilis R, Selikoff I J
J Environ Pathol Toxicol. 1978 Jul-Aug;1(6):897-910.
Traditionally, the diagnosis of lead intoxication has relied upon blood lead and urine lead determinations. However, metabolic changes in the biosynthetic pathway of heme as well as damage in other organ systems may occur at blood lead levels hitherto regarded as "safe." Lead intoxication leads to elevated zinc protoporphyrin (ZPP) levels in the blood which can be measured quickly, inexpensively and conveniently on a drop of unprocessed whole blood by means of a dedicated front face fluorometer, called a hematofluorometer. In the present study, ZPP showed a strong correlation with the lead-in-blood level, as well as with signs and symptoms of lead-related disease. It is concluded that zinc protoporphyrin determination offers a preferred primary screening test for lead-exposed populations.
传统上，铅中毒的诊断依赖于血铅和尿铅测定。然而，血红素生物合成途径的代谢变化以及其他器官系统的损伤可能在迄今被视为“安全”的血铅水平下发生。铅中毒会导致血液中锌原卟啉（ZPP）水平升高，通过一种称为血液荧光计的专用正面荧光计，可以对一滴未处理的全血进行快速、廉价且方便的测量。在本研究中，ZPP与血铅水平以及铅相关疾病的体征和症状密切相关。得出的结论是，锌原卟啉测定为铅暴露人群提供了一种首选的初步筛查测试。
