Sazontova T G, Glazachev O S, Bolotova A V, Dudnik E N, Striapko N V, Bedareva I V, Anchishkina N A, Arkhipenko Iu V
Ross Fiziol Zh Im I M Sechenova. 2012 Jun;98(6):793-807.
We have conducted theoretical foundation, experimental analysis and a pilot study of a new method of adaptation to hypoxia and hyperoxia in the prevention of hypoxic and stress-induced disorders and improving the body's tolerance to physical stress. It has been shown in the experimental part that a combination of physical exercise with adaptation to hypoxia-hyperoxia significantly increased tolerance to acute physical load (APL) and its active phase. Analysis of lipid peroxidation processes, antioxidant enzymes and HSPs showed that short-term training for physical exercise by itself compensates the stressor, but not the hypoxic component of the APL, the combination of training with adaptation to hypoxia-hyperoxia completely normalizes the stressor and hypoxic components of APL. The pilot study has been performed to evaluate the effectiveness of hypoxic-hyperoxic training course in qualified young athletes with over-training syndrome. After completing the course of hypoxia-hyperoxia adaptation, 14 sessions, accompanied by light mode sports training, the athletes set the normalization of autonomic balance, increased resistance to acute hypoxia in hypoxic test, increased physical performance--increased PWC170, maximal oxygen consumption (VO2max) parameters, their relative values to body mass, diminished shift of rate pressure product in the load. Thus, we confirmed experimental findings that hypoxic-hyperoxic training optimizes hypoxic (increased athletes resistance to proper hypoxia) and stress (myocardium economy in acute physical stress testing) components in systemic adaptation and restoration of athletes' with over-training syndrome.
我们对一种适应低氧和高氧的新方法进行了理论基础、实验分析和初步研究，该方法用于预防低氧和应激诱导的疾病，并提高身体对体力应激的耐受性。实验部分表明，体育锻炼与适应低氧-高氧相结合显著提高了对急性体力负荷（APL）及其活跃期的耐受性。对脂质过氧化过程、抗氧化酶和热休克蛋白的分析表明，单纯的体育锻炼短期训练可补偿应激源，但不能补偿APL的低氧成分，而训练与适应低氧-高氧相结合则可使APL的应激源和低氧成分完全正常化。已进行初步研究以评估低氧-高氧训练课程对患有过度训练综合征的优秀年轻运动员的有效性。在完成14次伴有轻度体育训练的低氧-高氧适应课程后，运动员的自主平衡恢复正常，在低氧测试中对急性低氧的抵抗力增强，体能提高——PWC170、最大耗氧量（VO2max）参数增加，其相对于体重的相对值增加，负荷中率压积的变化减小。因此，我们证实了实验结果，即低氧-高氧训练在系统性适应和恢复患有过度训练综合征的运动员方面优化了低氧（提高运动员对适当低氧的抵抗力）和应激（急性体力应激测试中的心肌经济性）成分。
