Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1.
J Am Chem Soc. 2012 Oct 10;134(40):16558-61. doi: 10.1021/ja308876j. Epub 2012 Sep 28.
Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.
我们使用负载上转换纳米粒子（UCNPs）的光敏感杂化水凝胶，展示了连续波近红外（NIR）光（980nm）可用于诱导凝胶-溶胶转变，并将水凝胶中包封的大的、无活性的生物大分子（蛋白质和酶）按需释放到水溶液中，从而恢复其生物活性。这项研究是利用 UCNPs 的独特多光子效应来开发用于生物医学应用的光敏感材料的新示范和新进展。
