阿拉伯联合酋长国急性冠状动脉综合征和心力衰竭患者的特征及院内结局

Characteristics and in-hospital outcomes of patients with acute coronary syndromes and heart failure in the United Arab Emirates.

作者信息

Shehab Abdulla, Al-Dabbagh Bayan, Almahmeed Wael, Bustani Nazar, Nagelkerke Nicolaas, Yusufali Afzal, Wassef Adel, Ibrahim Mohamed, Brek Azan Bin

机构信息

Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

出版信息

BMC Res Notes. 2012 Sep 26;5:534. doi: 10.1186/1756-0500-5-534.

DOI:10.1186/1756-0500-5-534

PMID:23014157

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3527184/

Abstract

BACKGROUND

Heart failure (HF) is a serious complication of acute coronary syndromes (ACS), and is associated with high in-hospital mortality and poor long-term survival. The aims of this study were to describe the clinical characteristics, management and in-hospital outcomes of coronary syndrome (ACS) patients with HF in the United Arab Emirates.

FINDINGS

The study was selected from the Gulf Registry of Acute Coronary Events (Gulf RACE), a prospective multi-national, multicenter registry of patients hospitalized with ACS in six Middle East countries. The present analysis was focused on participants admitted to various hospitals in the UAE with a diagnosis of ACS in 2007 and were analyzed in terms of HF (Killip class II/III and IV) on admission. Of 1691 patients (mean age: 52.6 ± 11.7 years; 210 Females, 1481 Males) with ACS, 356 (21%) had an admission diagnosis of HF (Killip class II/III and IV). HF patients were less frequently males (19.2% vs. 34.3%; P < 0.001). HF was more frequently associated with hypertension (64.3% vs. 43.9%; P < 0.001), hyperlipidemia (49.4% vs. 31.8%; P < 0.001) and diabetes mellitus (DM) (51.1% vs. 36.2%; P < 0.001). HF was significantly associated with in-hospital mortality (OR = 11.821; 95% CI: 5.385-25.948; P < 0.001). In multivariate logistic regression, age, hyperlipidemia, heart rate and DM were associated with higher in-hospital HF.

CONCLUSIONS

HF is observed in about 1 in 5 patients with ACS in the UAE and is associated with a significant increase in in-hospital mortality and other adverse outcomes.

摘要

背景

心力衰竭（HF）是急性冠状动脉综合征（ACS）的严重并发症，与住院期间的高死亡率和较差的长期生存率相关。本研究的目的是描述阿拉伯联合酋长国患有HF的冠状动脉综合征（ACS）患者的临床特征、治疗及住院结局。

研究结果

本研究选自海湾急性冠状动脉事件注册研究（Gulf RACE），这是一项针对中东六个国家因ACS住院患者的前瞻性多国多中心注册研究。本分析聚焦于2007年在阿联酋各医院确诊为ACS且入院时根据HF（Killip分级II/III和IV级）进行分析的参与者。在1691例ACS患者（平均年龄：52.6±11.7岁；女性210例，男性1481例）中，356例（21%）入院诊断为HF（Killip分级II/III和IV级）。HF患者中男性较少（19.2%对34.3%；P<0.001）。HF更常与高血压（64.3%对43.9%；P<0.001）、高脂血症（49.4%对31.8%；P<0.001）和糖尿病（DM）（51.1%对36.2%；P<0.001）相关。HF与住院死亡率显著相关（OR=11.821；95%CI：5.385-25.948；P<0.001）。在多因素逻辑回归分析中，年龄、高脂血症、心率和DM与住院期间发生HF风险较高相关。