Department of Chemistry, Box 30012, Texas A & M University, College Station, TX 77841-3012, USA.
Chem Soc Rev. 2013 Jan 7;42(1):77-88. doi: 10.1039/c2cs35216h. Epub 2012 Sep 26.
BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with (3)O(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.
BODIPY 染料往往具有很强的荧光性，但通过添加具有适当氧化电位的取代基，其发射可以被衰减。这些取代基具有电子，可以供给被光激发的 BODIPY，猝灭其荧光，从而产生相对长寿命的三重态。当这些三重态与（3）O（2）相互作用时，会形成单线态氧。在组织中，这会导致被照射区域的细胞损伤，这就是光动力疗法（PDT）的基础。目前批准用于临床的 PDT 试剂不含有 BODIPY，但有很多理由相信这种情况将会改变。本综述总结了 BODIPY 染料在 PDT 及一些相关领域的特性。
