Department of Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Arch Gynecol Obstet. 2013 Feb;287(2):329-35. doi: 10.1007/s00404-012-2571-4. Epub 2012 Sep 27.
To investigate the clinical features of aerobic vaginitis (AV) and mixed infections with AV to achieve efficient diagnosis.
From April 2008 to August 2009, 657 consecutive outpatients with vaginal symptoms in gynecology clinic in the General Hospital of Tianjin Medical University were investigated. Samples were taken for examination of vaginal discharge and fresh wet mount microscopy. AV, bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomonal vaginitis (TV) were diagnosed according to standardized definitions. Sixty patients with single AV were randomly selected over the same period. Each patient accepted moxifloxacin therapy. Two kinds of treatment course (400 mg qd, 6 days or 400 mg qd, 12 days) were given. Clinical features and laboratory test results in the first visit and follow-ups were recorded and statistically analyzed.
Among the 657 cases, AV was found in 23.74 % of the cases (156/657). AV mixed infections were diagnosed in 53.85 % (84/156): the mixed infections included VVC (32/84, 38.10 %), BV (31/84, 36.90 %), and TV (21/84, 25.00 %). Common symptoms of AV were a change in the characteristics of the discharge (44/72, 61.11 %) and increased discharge (30/72, 41.67 %). Vaginal pH was usually higher than 4.5 (63/72, 87.50 %). Enterococcus faecalis, Streptococcus viridans, Escherichia coli, and Staphylococcus epidermidis were frequently isolated. There is no statistically significant difference between two moxifloxacin treatment groups (p > 0.05). Cure rate was 89.7 % in 6-day group, and 71.4 % in 12-day group.
AV is a common vaginal infection, and it is often mixed with other infections, especially VVC, BV and TV. The symptoms and signs of AV mixed infections are atypical. If a patient has vaginal complaints, it is necessary to determine whether AV or mixed infections are present. Oral moxifloxacin is effective in treating AV, and an appropriate course should be selected taking the severity of AV into consideration.
探讨需氧性阴道炎（AV）的临床特征及混合感染情况，以实现有效诊断。
2008 年 4 月至 2009 年 8 月，天津医科大学总医院妇科门诊连续就诊的 657 例阴道症状患者接受了调查。采集阴道分泌物样本进行检查，并进行新鲜湿片显微镜检查。根据标准化定义诊断 AV、细菌性阴道病（BV）、外阴阴道假丝酵母菌病（VVC）和滴虫性阴道炎（TV）。同期随机选择 60 例单纯性 AV 患者，每位患者接受莫西沙星治疗。给予两种治疗疗程（400mgqd，6 天或 400mgqd，12 天）。记录首次就诊和随访时的临床特征和实验室检查结果，并进行统计学分析。
657 例患者中，AV 检出率为 23.74%（156/657）。诊断为 AV 混合感染的患者占 53.85%（84/156）：混合感染包括 VVC（32/84，38.10%）、BV（31/84，36.90%）和 TV（21/84，25.00%）。AV 的常见症状为分泌物特征改变（44/72，61.11%）和分泌物增多（30/72，41.67%）。阴道 pH 值通常高于 4.5（63/72，87.50%）。经常分离出粪肠球菌、草绿色链球菌、大肠埃希菌和表皮葡萄球菌。两种莫西沙星治疗组之间无统计学差异（p>0.05）。6 天组的治愈率为 89.7%，12 天组的治愈率为 71.4%。
AV 是一种常见的阴道感染，常与其他感染混合存在，尤其是 VVC、BV 和 TV。AV 混合感染的症状和体征不典型。如果患者有阴道不适，有必要确定是否存在 AV 或混合感染。口服莫西沙星治疗 AV 有效，应根据 AV 的严重程度选择适当的疗程。
