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The airway microbiota in cystic fibrosis: a complex fungal and bacterial community--implications for therapeutic management.囊性纤维化中的气道微生物群：复杂的真菌和细菌群落 - 对治疗管理的影响。
PLoS One. 2012;7(4):e36313. doi: 10.1371/journal.pone.0036313. Epub 2012 Apr 27.
2
Colonization by Pneumocystis jirovecii and its role in disease.肺孢子菌定植及其在疾病中的作用。
Clin Microbiol Rev. 2012 Apr;25(2):297-317. doi: 10.1128/CMR.00013-12.
3
Pneumocystis jirovecii multilocus genotyping in pooled DNA samples: a new approach for clinical and epidemiological studies.对聚合 DNA 样本进行肺孢子菌多基因座基因分型：一种用于临床和流行病学研究的新方法。
Clin Microbiol Infect. 2012 Jun;18(6):E177-84. doi: 10.1111/j.1469-0691.2012.03828.x. Epub 2012 Apr 4.
4
High prevalence of Pneumocystis jirovecii colonization in Brazilian cystic fibrosis patients.巴西囊性纤维化患者中耶氏肺孢子菌定植的高流行率。
Med Mycol. 2012 Jul;50(5):556-60. doi: 10.3109/13693786.2011.645892. Epub 2011 Dec 29.
5
Clinical significance of quantifying Pneumocystis jirovecii DNA by using real-time PCR in bronchoalveolar lavage fluid from immunocompromised patients.实时 PCR 定量检测免疫抑制患者支气管肺泡灌洗液中肺孢子菌 DNA 的临床意义。
J Clin Microbiol. 2012 Feb;50(2):227-31. doi: 10.1128/JCM.06036-11. Epub 2011 Dec 7.
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PCR diagnosis of Pneumocystis pneumonia: a bivariate meta-analysis.PCR 诊断卡氏肺孢子虫肺炎：双变量荟萃分析。
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7
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Pneumocystis jirovecii colonization in chronic pulmonary disease.肺孢子菌定植于慢性肺部疾病。
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法国囊性纤维化患者肺孢子菌定植的前瞻性多中心研究。

Prospective multicenter study of Pneumocystis jirovecii colonization among cystic fibrosis patients in France.

机构信息

Center for Infection and Immunity of Lille (CIIL), Institut Pasteur de Lille, Biology and Diversity of Emerging Eukaryotic Pathogens (BDEEP, EA4547), Lille, France.

出版信息

J Clin Microbiol. 2012 Dec;50(12):4107-10. doi: 10.1128/JCM.01974-12. Epub 2012 Sep 26.

DOI:10.1128/JCM.01974-12
PMID:23015669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3502982/
Abstract

Pneumocystis carriage was detected in 12.5% of 104 cystic fibrosis (CF) patients during a prospective multicenter French study, with a prevalence of genotype 85C/248C and geographic variations. It was significantly associated with the absence of Pseudomonas aeruginosa colonization and a greater forced expiratory volume in 1 s. Results are discussed considering the natural history of CF.

摘要

在一项前瞻性多中心法国研究中，104 例囊性纤维化 (CF) 患者中有 12.5%携带肺囊虫，其基因型为 85C/248C，存在地域差异。它与铜绿假单胞菌定植缺失和 1 秒用力呼气容积增加显著相关。结果结合 CF 的自然史进行了讨论。