法国囊性纤维化患者肺孢子菌定植的前瞻性多中心研究。
Prospective multicenter study of Pneumocystis jirovecii colonization among cystic fibrosis patients in France.
机构信息
Center for Infection and Immunity of Lille (CIIL), Institut Pasteur de Lille, Biology and Diversity of Emerging Eukaryotic Pathogens (BDEEP, EA4547), Lille, France.
出版信息
J Clin Microbiol. 2012 Dec;50(12):4107-10. doi: 10.1128/JCM.01974-12. Epub 2012 Sep 26.
Abstract
Pneumocystis carriage was detected in 12.5% of 104 cystic fibrosis (CF) patients during a prospective multicenter French study, with a prevalence of genotype 85C/248C and geographic variations. It was significantly associated with the absence of Pseudomonas aeruginosa colonization and a greater forced expiratory volume in 1 s. Results are discussed considering the natural history of CF.
摘要
在一项前瞻性多中心法国研究中，104 例囊性纤维化 (CF) 患者中有 12.5%携带肺囊虫，其基因型为 85C/248C，存在地域差异。它与铜绿假单胞菌定植缺失和 1 秒用力呼气容积增加显著相关。结果结合 CF 的自然史进行了讨论。
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